CRCU

Chemical Research in Chinese Universities ›› 2004, Vol. 20 ›› Issue (3): 270-273.

• Articles • Previous Articles     Next Articles

Synthesis and Characterization of 2-Decyl-DTPA and Its Gd(Ⅲ) Chelate

FENG Zhi-ming1, LI Feng1, CHEN Rong1, ZHU Xiao-juan1, LI Xiao-ru2   

  1. 1. College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China;
    2. College of Chemistry and Chemical Engineering, Centralsouth University, Changsha 410083, P. R. China
  • Received:2003-05-20 Online:2004-06-24 Published:2011-08-06
  • Supported by:

    Supported by the Fund of Science and Technology Department of Hunan Province(No.OOSSY1013-51).

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Abstract: The present paper covers the synthesis and the characterization of ligand 2-decyl-3, 6, 9-tris(carboxymethyl)-3,6,9-triazaundecan-1,11-dioic acid, H5L, and its Gd(Ⅲ) chelate. The protonation constants for H5L(lgKiH=10.90, 8.50, 4.55, 2.92, 2.20) and the stability constant for GdL2- (lgKGdL2-=22.80) were determined by means of potentiometric titration. They are similar to the corresponding values of DTPA and Gd-DTPA, respectively. The results obtained show that the basicity of the ligand and the stability constant of its Gd(Ⅲ) chelate are not obviously altered after the introduction of a linear chain decyl group into the terminal acetic acid residue of DTPA. The Gd(Ⅲ) chelate may be a potential contrast agent with liver-specificity for magnetic resonance imaging(MRI).

Key words: Gd(Ⅲ) chelate, DTPA derivative, Contrast agent