Lipophilic Enhance of Vitamin C Protective Activity Against Free-radical-induced Damage in vivo

Chemical Research in Chinese Universities ›› 2003, Vol. 19 ›› Issue (4): 428-431.

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Lipophilic Enhance of Vitamin C Protective Activity Against Free-radical-induced Damage in vivo

LUO Xu-yang¹, LIU Zai-qun¹, SUN Yun-xiu¹, SUI Da-yuan², YU Xiao-feng², QU Shao-chun²

1. College of Chemistry, Jilin University, Changchun 130023, P. R. China;
2. College of Pharmacy, Jilin University, Changchun 130021, P. R. China

Received:2002-02-25 Online:2003-12-24 Published:2011-08-06
Supported by:
Supported by the Jilin Provincial Government Department of Science and Technology, China(No.20000502).

Abstract

Abstract: A group of experimental rats under free radical damage are given various amounts of a lipophilic vitamin C(ascorbyl-6-laurate, VC-12), and its parent compound, vitamin C, respectively. It has been found that the effects of 1.12 mmol/kg VC-12 on decreasing triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-c) and lipid peroxide(LPO), and increasing high density lipoprotein cholesterol(HDL-c) and superoxide dismutase(SOD) are similar to those of 2.27 mmol/kg vitamin C. In addition, VC-12(1.12 mmol/kg) can increase the prostacycline(PGI₂) and decrease the thromboxane(TXA₂) even better than vitamin C(2.27 mmol/kg). The above facts demonstrate that the antioxidative activity of VC-12 is higher than twice that of vitamin C. So, ascorbyl-6-laurate may be a novel antioxidant drug against free radical damage.

Key words: Antioxidant, Free radical, Ascorbyl-6-laurate, Vitamin C, Blood lipid metabolism, in vivo

LUO Xu-yang, LIU Zai-qun, SUN Yun-xiu, SUI Da-yuan, YU Xiao-feng, QU Shao-chun. Lipophilic Enhance of Vitamin C Protective Activity Against Free-radical-induced Damage in vivo[J]. Chemical Research in Chinese Universities, 2003, 19(4): 428-431.

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Lipophilic Enhance of Vitamin C Protective Activity Against Free-radical-induced Damage in vivo

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