Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

Chemical Research in Chinese Universities ›› 2002, Vol. 18 ›› Issue (1): 16-19.

• Articles • Previous Articles Next Articles

Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

DENG Guang-hui¹, WEI Shou-lian¹, MO Jin-yuan²

1. Department of Chemistry, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Department of Chemistry, Zhongshan University, Guangzhou 510275, P. R. China

Received:2000-10-18 Online:2002-01-24 Published:2011-08-04
Supported by:
Supported by the Natural Science Foundation of Guangxi Province(No.9912001).

Abstract

Abstract: In the nonaqueous N,N-dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl-β-cyclodextrin(s-β-CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS(β-CD, diethylic-β-CD, sulfonyl-β-CD) on the chiral separation was made and the resolution mechanism was proposed.

Key words: Nonaqueous medium, Capillary electrophoresis with conductance detection, Sulfonyl β-CD, Resolution, N,N-Dimethylformamide

DENG Guang-hui, WEI Shou-lian, MO Jin-yuan. Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection[J]. Chemical Research in Chinese Universities, 2002, 18(1): 16-19.

[1]	ZHANG Kejie, ZHANG Min, LIU Huan. Printing High-resolution Micro-patterns by Solution Processes [J]. Chemical Research in Chinese Universities, 2021, 37(5): 1008-1018.
[2]	SHEN Qifei, XU Ruohan, WANG Zhi, ZHAO Tianyu, ZHOU Yu, XU Yanzi, YANG Zhiwei, LEI Ming, MENG Lingjie, DANG Dongfeng. Donor-Acceptor Typed AIE Luminogens with Near-infrared Emission for Super-resolution Imaging [J]. Chemical Research in Chinese Universities, 2021, 37(1): 143-149.
[3]	ZHANG Shuo, WANG Wenjin, LI Chuan, LIU Peng, XU Weiren, TANG Lida, WANG Jianwu, ZHAO Guilong. Facile Synthesis of Enantiomerically Pure1-(5-Bromo-2-chlorophenyl)-1-(4-ethoxyphenyl)ethane [J]. Chemical Research in Chinese Universities, 2014, 30(2): 250-256.
[4]	WU Nan, SUN Kun-lun, LIU Yu, YANG Xiao-feng, LI Hua. Multivariate Curve Resolution Combined with On-line Infrared Spectroscopy for Researching the Synthesis Mechanism of 3,4-Bis(4’-aminofurazano-3’)furoxan [J]. Chemical Research in Chinese Universities, 2013, 29(4): 759-764.
[5]	WANG Zhi-yuan, LIU Jun-zhong, XU Li-sheng, ZHANG Hong-juan, LIU Qian, JIAO Qing-cai. Preparation of Optically Active Alkoxy-serines from Amino-amide Racemate Catalyzed by Escherichia coli Cells with Peptidase B Activity [J]. Chemical Research in Chinese Universities, 2013, 29(1): 95-98.
[6]	ZHANG Wei-guo, ZHAO Gen-hai, LIU Jun-zhong, LIU Qian and JIAO Qing-cai*. Enzymatic Synthesis of Agmatine by Immobilized Escherichia coli Cells with Arginine Decarboxylase Activity [J]. Chemical Research in Chinese Universities, 2011, 27(6): 992-995.
[7]	AN Bai-yi, XIE Xiao-na, XUN Er-na, WANG Jia-xin, WANG Ren, SUN Ruo-xi, WANG Lei* and WANG Zhi*. Ultrasound-promoted Lipase-catalyzed Enantioselective Transesterification of (R,S)-Glycidol [J]. Chemical Research in Chinese Universities, 2011, 27(5): 845-849.
[8]	LIANG Xu, ZHANG Xi, XU Zhi-xiu, LIU Hui, HE Ya-jun, LV Yong-hai and ZHANG Wei-dong. Rapid Quantification of Chinese Medicine Zuo Jin Pill via RRLC [J]. Chemical Research in Chinese Universities, 2010, 26(6): 905-909.
[9]	ZHENG Liang-yu, ZHANG Suo-qin*, Lü Xiao-li and CAO Shu-gui. Synthesis of (S)-N-(2-Ethyl-6-methylphenyl)alanine by Enzyme-catalyzed Resolution and Chemical Racemization [J]. Chemical Research in Chinese Universities, 2009, 25(6): 836-840.
[10]	ZHANG Da-tong , TANG Li-da , DUAN Gui-yun , ZHAO Gui-long , XU Wei-ren , MENG Li-juan , WANG Jian-wu . Synthesis, Resolution, and Enantiomeric Purity Assay of 2-n-Butylbutanedioic Acid 4-t-Butyl Esters [J]. Chemical Research in Chinese Universities, 2006, 22(5): 584-588.
[11]	ZHANG Da-tong, TANG Li-da, DUAN Gui-yun, ZHAO Gui-long, XU Wei-ren, MENG Li-juan, WANG Jian-wu. Synthesis, Resolution, and Enantiomeric Purity Assay of 2-n-Butylbutanedioic Acid 4-t-Butyl Esters [J]. Chemical Research in Chinese Universities, 2006, 22(5): 584-588.
[12]	WANG Zhi, LI Zheng-qiang, Yu Da-hai, WENG Liang, LIU Ming, ZHANG Gui-rong, CAO Shu-gui. Resolution of 2-Octanol via Lipase-catalyzed Enantioselective Acetylation in Organic Solvents [J]. Chemical Research in Chinese Universities, 2004, 20(5): 575-578.
[13]	YANG Hui, QIU Guo-fu, FENG Xi-chun, HE Jian-she, HU Xian-ming. Hydrolysis Reactions and Resolution of (±)-2-Acetamido-3-hydroxy-1-(4-nitrophenyl)-1-propanone [J]. Chemical Research in Chinese Universities, 2002, 18(4): 409-411.
[14]	Zhang Yawen, Shen Zongxuan . Improved Synthesis and Resolution of α-N-Benzoyl-β(3-Qumolyl)-DL-α-Alanine Methyl Ester [J]. Chemical Research in Chinese Universities, 1991, 7(4): 261-265.

Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 14

Recommended Articles

Metrics

Comments