Recognition of Protein Native Folds Using a Continuous Potential Function

Chemical Research in Chinese Universities ›› 1994, Vol. 10 ›› Issue (2): 134-140.

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Recognition of Protein Native Folds Using a Continuous Potential Function

WANG Yu-hong, LU Zhi-bin, LI Wei

Department of Molecular Biology, Jilin University, Changchun, 130023

Received:1993-07-03 Online:1994-04-24 Published:2011-08-17
Supported by:
Supported by the National Natural Science Houndation of China(39270182) and US National Science Foundation(INT-9107818).

Abstract

Abstract: We report a simple continuous potential function that can recognize proteinchains' native folds from tens of thousands of alternative ones.Empirical parame-ters for this potential function were obtained by a neural network learning oversamples generated from PDBstructural data.Hydrophobic interactions were foundto be mainly responsible for stabilization of the protein' s native fold.The inter-chain interaction was found indispensable in stabilizing some protein chains' nativeconformation.

Key words: Recognition, Protein native fold, Function

WANG Yu-hong, LU Zhi-bin, LI Wei. Recognition of Protein Native Folds Using a Continuous Potential Function[J]. Chemical Research in Chinese Universities, 1994, 10(2): 134-140.

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Recognition of Protein Native Folds Using a Continuous Potential Function

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