Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA

Chemical Research in Chinese Universities ›› 1990, Vol. 6 ›› Issue (1): 67-72.

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Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA

Li Rongchang, Gao Fei, Wang Kui

Department of Inorganic Chemistry, Beijmg Medical University, Beijing

Received:1989-12-04 Online:1990-01-24 Published:2011-09-09
Supported by:
This study was supported by National Natural Science Foundation of China.

Abstract

Abstract: Cd, Zn-thionelns were isolated from the rat liver by improved Winge method and purified further. The composition was determined. The mobilization of Cd ions from the Cd, Zn-metallothioneins was studied with spectrophotometric method. The results show that the reaction of DTP Aor EDTAwith Cd, Zn-thioneins occurs through three steps. The first step follows pseudo-first order reaction with association mechanism. The formation constants and the dissociation rate constants of the relevant intermediate ternary complexes and apparent rate constants, K_app were determined. The properties and structure of Cd, Zn-thioneins and ligands with low molecular weights affect the values of K_app.

Key words: Metallothionein, Substitution reactions, Kinetics

Li Rongchang, Gao Fei, Wang Kui . Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA[J]. Chemical Research in Chinese Universities, 1990, 6(1): 67-72.

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Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA

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