NIR-II Organic Cocrystals for Photothermal Therapy

doi:10.1007/s40242-025-5240-4

Abstract

Abstract: Photothermal therapy (PTT) is a promising alternative strategy to traditional cancer therapy. Photothermal agents (PTAs) in the second near-infrared (NIR) window (1000—1350 nm) hold excellent potential for enhanced PTT treatment of deep tumors compared with the first NIR window (780—1000 nm). Therefore, by regulating intermolecular charge transfer interactions, we employed coprecipitation method to synthesize two photothermal cocrystals nanoparticles (NPs) named 3,3':4',3''-terthiophene-7,7,8,8-tetracyanoquinodimethane (3TTQ) NPs and 3,3':4',3''-terthiophene-2,3,5,6-tetrafluoro-7,7,8,8-tetracyano- quinodimethane (3TFQ) NPs, which exhibited excellent absorption properties, with their absorption range red-shifted to 1150 and 1350 nm, respectively. Under 808 and 1064 nm laser irradiation, the power conversion efficiencies (PCEs) reached 67.3% and 69%, simultaneously, exhibiting concentration and power density dependence. Additionally, 3TFQ NPs not only exhibited excellent biocompatibility, but also demonstrated photothermal therapeutic efficacy in vitro under 1064 nm laser irradiation, achieving a 70% death rate in 4T1 cancer cells at a concentration of 100 μg/mL. This study contributes to the advancement of developing NIR-II organic cocrystals PTAs.

Key words: Organic cocrystal, Charge transfer, Near-infrared region II (NIR-II), Photothermal therapy

HE Junxia, ZHANG Tian, ZHANG Dong, ZHANG Xiaotao, HU Wenping. NIR-II Organic Cocrystals for Photothermal Therapy[J]. Chemical Research in Chinese Universities, 2025, 41(6): 1653-1662.

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