Chemical Research in Chinese Universities ›› 2024, Vol. 40 ›› Issue (1): 145-152.doi: 10.1007/s40242-023-3248-1

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Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

WU Jun1, LI Yongzhi1, QIN Hanjiao2, GAO Ying3, YANG Bing3, SHENG Jiyao1, ZHANG Xuewen1   

  1. 1. Department of Hepatobiliary and Pancreatic Surgery, the Second Hospital of Jilin University, Changchun 130022, P. R. China;
    2. Department of Radiation Oncology, the Second Hospital of Jilin University, Changchun 130022, P. R. China;
    3. State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China
  • Received:2023-11-08 Online:2024-02-01 Published:2024-01-24
  • Contact: YANG Bing, SHENG Jiyao, ZHANG Xuewen;;
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (Nos. 82002809, 81902484, 52103209), the China Postdoctoral Science Foundation (No. 2020M670864), the Medical and Health Talents Project of Jilin Province, China (No. 2020SCZT097), the Youth Support Project of Jilin Association for Science and Technology, China (No. 202028), the Jilin Provincial Science and Technology Development Plan, China (No. 20210204028YY), and the Natural Science Foundation of Jilin Province, China (No. YDZJ202301ZYTS080).

Abstract: In this study, we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino) phenyl) naphtho[2,3-c] [1,2,5] thiadiazol-4-yl) phenyl)-1H-phenol-1-ylidene) malononitrile (TPA). Furthermore, TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with PEG2000. TPA-PEG2000 exhibited strong near-infrared emission near 700 nm, with a photoluminescence quantum yield of 15.09%, indicating a high emission efficiency. Molecular biology experiments have confirmed its low toxicity and excellent biocompatibility. Increased cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity, reduced membrane fluidity, reduced endocytic efficiency, and reduced uptake. Therefore, the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

Key words: Nanoparticle, Near-infrared, Fluorescence, Systemic treatment sensitivity, Cell membrane fluidity