A Highly Efficient Aggregation-induced Emission Photosensitizer for Photodynamic Combat of Multidrug-resistant Bacteria

doi:10.1007/s40242-021-0393-2

Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (1): 150-156.doi: 10.1007/s40242-021-0393-2

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A Highly Efficient Aggregation-induced Emission Photosensitizer for Photodynamic Combat of Multidrug-resistant Bacteria

ZOU Qian¹, WANG Jia-Li¹, WU Ming-Yu^1,2, KAM Chuen², LEE Sin-Ying², FENG Shun¹, CHEN Sijie²

1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China;
2. Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, P. R. China

Received:2020-11-27 Revised:2020-12-24 Online:2021-02-01 Published:2021-02-03
Contact: WU Ming-Yu, CHEN Sijie E-mail:wumy1050hx@swjtu.edu.cn;sijie.chen@ki.se
Supported by:
This work was supported by the National Natural Science Foundation of China(No.21708030) and the Start-up Funding from Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet.

Abstract

Abstract: With the antibiotic abuse and the resulting increased antibiotic resistance, the bacterial infection has posed a serious threat to human health. Photodynamic therapy is an effective tool for treating localized and superficial infections. It is a promising approach for the treatment of superbugs and with minimal risk of induced antibiotic resistance. Herein, an isoquinolinium-based photosensitizer, LIQ-TPE, with aggregation-induced emission properties is designed and synthesized. It is with high ¹O₂ generation efficiency and shows efficient antibacterial performance towards both Gram-negative and Gram-positive bacteria, and even methicillin-resistant Staphylococcus aureus(MRSA). LIQ-TPE thus shows great promise as an effective antimicrobial agent to combat the menace of multi-drug resistant bacteria.

Key words: Aggregation-induced emission, Photosensitizer, Isoquinolinium, Photodynamic antibiosis

ZOU Qian, WANG Jia-Li, WU Ming-Yu, KAM Chuen, LEE Sin-Ying, FENG Shun, CHEN Sijie. A Highly Efficient Aggregation-induced Emission Photosensitizer for Photodynamic Combat of Multidrug-resistant Bacteria[J]. Chemical Research in Chinese Universities, 2021, 37(1): 150-156.

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A Highly Efficient Aggregation-induced Emission Photosensitizer for Photodynamic Combat of Multidrug-resistant Bacteria

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