Facile Synthesis of Unsymmetrical N-Aryl-2, 2-di(1H-indol-3-yl) Acetamide Derivatives

doi:10.1007/s40242-016-6233-0

Abstract

Abstract:

A facile and highly efficient method has been developed for the synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl)acetamide derivatives by regioselective Friedel-Crafts alkylation of the N-aryl-2-hydroxy-2-(1H-indol-3-yl) acetamide derivatives with various indoles catalyzed by 2 mol/L H₂SO₄ at room temperature in a short reaction time, the yield was up to 94%.

Key words: N-Aryl-2,2-di(1H-indol-3-yl)acetamide derivative, Indole, Unsymmetry, Friedel-Crafts alkylation, Brø, nsted acid

ZHOU Yan, LI Renjun, WANG Xiaolong, HE Ling, GUAN Mei, WU Yong. Facile Synthesis of Unsymmetrical N-Aryl-2, 2-di(1H-indol-3-yl) Acetamide Derivatives[J]. Chemical Research in Chinese Universities, 2016, 32(6): 959-966.

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