Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (2): 200-205.doi: 10.1007/s40242-017-6382-9

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Potassium tert-Butanolate Promoted Reaction of Benzaldehydes and Indoles: a New Strategy for Synthesis of Bis(indolyl) arylmethanes

JIANG Chong1, LI Jue1, LÜ Guanghui1,2, ZHENG Yang1, YU Xinling1, LÜ Songyang1, HAI Li1, WU Yong1   

  1. 1. Key Laboratory of Drug-targeting, Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China;
    2. Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, P. R. China
  • Received:2016-09-14 Revised:2016-10-08 Online:2017-04-01 Published:2016-11-28
  • Contact: WU Yong,E-mail:wyong@scu.edu.cn E-mail:wyong@scu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.81373259, 81573286).

Abstract:

t-BuOK-promoted synthesis of bis(indolyl) arylmethanes from aromatic aldehydes and indoles was achieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, are well tolerated under the optimal condition, making this reaction particularly attractive for expanding the scope of the present protocols that provides bis(1H-indol-3-yl) arylmethanes.

Key words: Bis(indolyl) arylmethane, Indole, Base-promoted reaction