Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (6): 941-946.doi: 10.1007/s40242-014-4120-0

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Synthesis of Resveratrol Analogs/Stilbene Derivatives and Their Nitric Oxide Inhibitory and Radical Scavenging Activities

WANG Jue1, ZHANG Cunlong3, WANG Tiejie1, LI Xiaofan2   

  1. 1. Shenzhen Institute for Drug Control, Shenzhen 518057, P. R. China;
    2. Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, P. R. China;
    3. Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China
  • Received:2014-04-04 Revised:2014-08-18 Online:2014-12-01 Published:2014-09-01
  • Contact: LI Xiaofan E-mail:lixiaof@szu.edu.cn
  • Supported by:

    Supported by the Shenzhen Science and Technology Program, China(No.JCYJ20120830153011458), the Project of the Educational Commission of Guangdong Province of China(No.2013KJCX0164) and the Natural Science Foundation of Shenzhen Universitiy, China(No.00036159).

Abstract:

Sixteen resveratrol analogs(stilbene derivatives) including resveratrol were synthesized, in which hydroxystilbenes, naturally occurring polyphenols, showed protective effects against reactive oxygen and nitrogen species(ROS/RNS) and hexahydroxystilbene(16) displayed the strongest activities against NO and 1,1-diphenyl- 2-picrylhydrazyl(DPPH) with IC50 values of 7.8 and 5.7 μmol/L, respectively.

Key words: Resveratrol, Stilbene, Nitric oxide, Radical