CRCU

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (3): 396-399.doi: 10.1007/s40242-014-3442-2

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Enzymatic Promiscuity：“Amano” Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media

JIANG Ling, YU Hongwei   

  1. Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, P. R. China
  • Received:2013-10-15 Revised:2013-11-15 Online:2014-06-01 Published:2013-12-11
  • Contact: YU Hongwei E-mail:yuhongwei@zju.edu.cn
  • Supported by:

    Supported by the Program for Zhejiang Leading Team of Science & Technology Innovation, China(No.2011R50007), the National Natural Science Foundation of China(Nos.21176215, 21176102) and the Outstanding Young Scholar Grant of Zhejiang University, China(No.R4110092).

Abstract:

"Amano" lipase AS(lipase from Aspergillus niger), which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.

Key words: “Amano&rdquo, lipase AS, Catalytic promiscuity, Multi-component reaction, Naphthopyran derivative