Design, Synthesis and Insecticidal Activities of Novel 5-Alkoxyfuran-2(5H)-one Derivatives

doi:10.1007/s40242-019-9122-5

Chemical Research in Chinese Universities ›› 2019, Vol. 35 ›› Issue (5): 799-805.doi: 10.1007/s40242-019-9122-5

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Design, Synthesis and Insecticidal Activities of Novel 5-Alkoxyfuran-2(5H)-one Derivatives

WANG Xianhao¹, LI Jianguo², WANG Guangjian³, HAN Xianzheng², LI Dongmei¹, TIAN Zhongzhen¹

1. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 266042, P. R. China;
2. Research and Development Center, Hailir Pesticides and Chemicals Group Co., Ltd., Qingdao 266109, P. R. China;
3. State Key Laboratory Base for Eco-Chemical Engineering in College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

Received:2019-04-24 Online:2019-10-01 Published:2019-09-24
Contact: TIAN Zhongzhen E-mail:chm_tianzz@ujn.edu.cn
Supported by:
Supported by the Natural Science Foundation of Shandong Province, China(No.ZR2018MB013), the National Natural Science Foundation of China(No.21501066) and the Key Research and Development Program of Shandong Province, China (No.2016GGX107006).

Abstract

Abstract: A series of novel 5-alkoxyfuran-2(5H)-one derivatives was synthesized, and characterized by ¹H NMR, ¹³C NMR and HRMS. Biological activities of all the title compounds were evaluated systematically. Preliminary bioassays indicated that most of the compounds exhibited moderate insecticidal activities against Aphis craccivora and Nilaparvata lugens at 100 mg/L. Compounds 4h and 4w exhibited 100% mortality rate against Aphis craccivora at 100 mg/L, and compound 4h exhibited good mortality rate against Aphis craccivora and Nilaparvata lugens (60% and 75%, respectively) even at 4 mg/L. The results demonstrated the impact of various chemical groups on insecticidal activities and provided a potential clue for further exploring novel high-effective broad-spectrum insecticides.

Key words: Butenolide derivative, Flupyradifurone, Neonicotinoid, Insecticidal activity

WANG Xianhao, LI Jianguo, WANG Guangjian, HAN Xianzheng, LI Dongmei, TIAN Zhongzhen. Design, Synthesis and Insecticidal Activities of Novel 5-Alkoxyfuran-2(5H)-one Derivatives[J]. Chemical Research in Chinese Universities, 2019, 35(5): 799-805.

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Design, Synthesis and Insecticidal Activities of Novel 5-Alkoxyfuran-2(5H)-one Derivatives

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