Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

doi:10.1007/s40242-014-4039-5

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (6): 959-964.doi: 10.1007/s40242-014-4039-5

• Articles • Previous Articles Next Articles

Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

WANG Li^1,2, WANG Liping³, XU Tianshu³, GUO Changrun³, LIU Chuanzhi⁴, ZHANG Hao⁵, LI Jing⁵, LIANG Zhiqing¹

1. Department of Obstetrics & Gynecology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, P. R. China;
2. The 208 Hospital of PLA, Changchun 130062, P. R. China;
3. College of Life Science, Jilin University, Changchun 130012, P. R. China;
4. College of Life Science, Changchun University of Science and Technology, Changchun 130012, P. R. China;
5. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P. R. China

Received:2014-01-27 Revised:2014-08-04 Online:2014-12-01 Published:2014-11-20
Contact: LIANG Zhiqing E-mail:zhi.lzliang@gmail.com
Supported by:
Supported by the Natural Science Foundation of Jilin Province, China(Nos.201015171, YYZX201150-2, 201205017, 12SF23).

Abstract

Abstract:

In this work, we synthesized the polypyrrole(PPy) modified gold nanoparticles and demonstrated their negligible cytotoxicity in vitro. These nanoparticles have also been demonstrated to efficiently ablate different kinds of tumor cells in vitro under the irradiation of the near-infrared laser. When the PPy modified gold nanoparticles were conjugated with the tumor-targeted molecule of 15P(sequence: SHSWHWLPNLRHYAS), these conjugates displayed hyperthermia effects on the human ovarian cancer cell line SK-OV-3 cells in vitro under the irradiation of near-infrared laser, showing great tumor-targeted treatment efficiency. To determine the potential hyperthermia effect of PPy modified gold nanoparticles or 15P-conjugate on tumor cells in vivo, the SK-OV-3 cells were used to induce the subcutaneous tumor-bearing nude mice. The significant inhibition effects of near-infrared laser mediated PPy modified gold nanoparticles or 15P-conjugate on the tumor growth were observed. These composite results suggest that the 15P-conjugated PPy modified gold nanoparticles exhibit great biocompatibility, particularly tumor-targeted effect and the effective photothermal ablation of tumor cells, which warrants the potential therapeutic value of this conjugate for further application to the in vivo localized tumor therapy.

Key words: Gold nanorod, Photothermal therapy, SK-OV-3 cell, Tumor cell

WANG Li, WANG Liping, XU Tianshu, GUO Changrun, LIU Chuanzhi, ZHANG Hao, LI Jing, LIANG Zhiqing. Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer[J]. Chemical Research in Chinese Universities, 2014, 30(6): 959-964.

References

[1] Gazelle G. S., Goldberg S. N., Solbiati L., Livraghi T., Radiology, 2000, 217, 633
[2] Sathornsumetee S., Rich J. N., Anticancer Drugs, 2006, 17, 1003
[3] Horsman M. R., Overgaard J., Clin. Oncol. R. Coll. Radiol., 2007, 19, 418
[4] Stauffer P. R., Int. J. Hyperthermia, 2005, 21, 731
[5] Eichler K., Mack M. G., Straub R., Engelmann K., Zangos S., Woitaschek D., Vogl T. J., Radiologe, 2001, 41, 915
[6] Issels R. D., Abdel-Rahman S., Wendtner C., Falk M. H., Kurze V., Sauer H., Aydemir U.,Hiddemann W., Eur. J. Cancer, 2013, 7, 1599
[7] van der Zee J., Gonzalez D., van Rhoon G. C., van Dijk J. D., van Putten W. L., Hart A. A., Lancet, 2000, 355, 1119
[8] Wust P., Hildebrandt B., Sreenivasa G., Rau B., Gellermann J., Riess H., Felix R., Schlag P. M., Lancet Oncol., 2002, 3, 487
[9] Ferrari M., Nat. Rev. Cancer, 2005, 5, 161
[10] Hirsch L. R., Stafford R. J., Bankson J. A., Sershen S. R., Rivera B., Price R. E., Hazle J. D., Halas N. J., West J. L., Proc. Natl. Acad. Sci. USA, 2003, 100, 13549
[11] Huang X., Jain P. K., El-Sayed I. H., El-Sayed M. A., Nanomedicine, 2007, 2, 681
[12] Murphy C. J., Sau T. K., Gole A. M., Orendorff C. J., Gao J., Gou L., Hunyadi S. E., Li T., J. Phys. Chem. B, 2005, 109, 13857
[13] Huang X., El-Sayed I. H., Qian W., El-Sayed M. A., J. Am. Chem. Soc., 2006, 128, 2115
[14] Li J., Han J. S., Xu T. S., Guo C. R., Bu X. Y., Zhang H., Wang L. P., Sun H. C., Yang B., Langmuir, 2013, 29, 7102
[15] Huang X., Jain P. K., El-Sayed I. H., El-Sayed M. A., Lasers Med. Sci., 2008, 23, 217
[16] Marches R., Mikoryak C., Wang R. H., Pantano P., Draper R. K., Vitetta E. S., Nanotechnology, 2011, 22, 95101
[17] Prickett W. M., van Rite B. D., Resasco D. E., Harrison R. G., Nanotechnology, 2011, 22, 45510
[18] Zhu L. F., Liang Z. Q., Wang L., Xu Y., Zhang G. Y., Journal of Third Military Medical University, 2010, 32, 891
[19] Li J., Wu J., Zhang X., Liu Y., Zhou D., Sun H. Z., Zhang H., Yang B., J. Phys. Chem. C., 2011, 115, 3630
[20] Zhang H. T., Chen G. G., Zhang Z. Y., Chun S., Leung B. C. S., Lai P. B. S., Apoptosis, 2012, 17, 325
[21] Lee K. S., El-Sayed M. A., J. Phys. Chem. B., 2006, 110, 19220
[22] Rayavarapu R. G., Petersen W., Hartsuiker L., Chin P., Janssen H., van Leeuwen F. W. B., Otto C., Manohar S., van Leeuwen T. G., Nanotechnology, 2010, 21, 145101
[23] Grabinski C., Schaeublin N., Wijaya A., D'Couto H., Baxamusa S. H., Hamad-Schifferli K., Hussain S. M., ACS Nano., 2011, 5, 2870
[24] Link S., El-Sayed M. A., Annu. Rev. Phys. Chem., 2003, 54, 331
[25] Huang X., Jain P. K., El-Sayed I. H., El-Sayed M. A., Photochem. Photobiol., 2006, 82, 412
[26] Jain P. K., Qian W., El-Sayed M. A., J. Am. Chem. Soc., 2006, 128, 2426
[27] Loo C., Hirsch L., Lee M. H., Chang E., West J., Halas N., Drezek R., Opt. Lett., 2005, 30, 1012
[28] Kopwitthaya A., Yong K. T., Hu R., Roy I., Ding H., Vathy L. A., Bergey E. J., Prasad P. N., Nanotechnology, 2010, 21, 315101

Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 7

Recommended Articles

Metrics

Comments

[1]	WU Liting, XIN Yujia, GUO Zhaoyang, GAO Wei, ZHU Yanpeng, br, WANG Yinsong, RAN Ruixue, YANG Xiaoying. Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer [J]. Chemical Research in Chinese Universities, 2022, 38(2): 562-571.
[2]	YU Qing, HUANG Xuan, ZHANG Tian, WANG Weili, YANG Dongliang, SHAO Jinjun, DONG Xiaochen. Near-infrared Aza-BODIPY Dyes Through Molecular Surgery for Enhanced Photothermal and Photodynamic Antibacterial Therapy [J]. Chemical Research in Chinese Universities, 2021, 37(4): 951-959.
[3]	FU Xuancheng, BAI Haotian, LYU Fengting, LIU Libing, WANG Shu. Conjugated Polymer Nanomaterials for Phototherapy of Cancer [J]. Chemical Research in Chinese Universities, 2020, 36(2): 237-242.
[4]	CHE Yuping, WANG Yang, YOU Tingting, CHANG Huaiqiu, YIN Penggang, ZHAI Jin. Multispectral Plasmon of Anisotropic Core-shell Gold Nanorods@SiO₂: Dual-band Absorption Enhancement with Coupling Dye Molecules [J]. Chemical Research in Chinese Universities, 2018, 34(5): 772-780.
[5]	LI Qin-hua, ZHU Ji-hong, LIU Lei, YUE Ying. Knockdown of STAT3 by iRNA Inhibiting Migration and Invasion of Epithelial Ovarian Cancer Cells [J]. Chemical Research in Chinese Universities, 2012, 28(5): 856-861 .
[6]	GUO Xing-gang, DONG Xin-shu , CHEN Jie. Tetraarsenic Tetrasulfide Induced Colon Cancer ls174t Cells Apoptosis [J]. Chemical Research in Chinese Universities, 2009, 25(2): 193-197.
[7]	CHEN Jie, DONG Xin-shu , GUO Xing-gang. Functional Mechanism of Resveratrol in Inhabiting Growth of Cells ls174t and Its Mechanism in Subcutaneously Transplanted Tumor of Nude Mice [J]. Chemical Research in Chinese Universities, 2008, 24(6): 756-761.