Design and Synthesis of Hydrazine and Oxadiazole-containing Derivatives of Sorafenib as Antitumor Agents

doi:10.1007/s40242-013-2490-3

Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (3): 454-459.doi: 10.1007/s40242-013-2490-3

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Design and Synthesis of Hydrazine and Oxadiazole-containing Derivatives of Sorafenib as Antitumor Agents

WANG Yuan-you¹, LIU Jian-zhen¹, YU Xiao-yue¹, YANG De-zhi¹, ZHANG Lin-na², ZHAO Gui-sen¹

1. Key Laboratory of Chemical Biology, Ministry of Education, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P. R. China;
2. Qilu Hospital, Shandong University, Jinan 250012, P. R. China

Received:2012-12-10 Revised:2013-03-01 Online:2013-06-01 Published:2013-05-15
Contact: Gui-Sen ZHAO E-mail:linnazhang62@yahoo.com.cn; guisenzhao@sdu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.21072115) and the Student Training Programs for Innovation of Shandong University, China(No.201210422076).

Abstract

Abstract:

A series of hydrazine and oxadiazole analogs of Sorafenib was designed, synthesized and characterized by proton nuclear magnetic resonance(¹H NMR) spectrometry and high resolution mass spectrometry(HRMS). The antiproliferative activities of these compounds against human colorectal carcinoma(HCT-116) and human breast cancer (MDA-MB-231) tumor cell lines were evaluated in vitro by MTT method[MTT=3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide]. The bioassay results suggest that most of the synthesized compounds have antitumor potential to HCT-116 cell line compared with MDA-MB-231 cell line. Compounds 8a,8b,8d, 8e,9f and 9j competitive with Sorafenib demonstrated antiproliferative activities on HCT-116 cell line.

Key words: Sorafenib analog, Antiproliferative activity, Antitumor agent

WANG Yuan-you, LIU Jian-zhen, YU Xiao-yue, YANG De-zhi, ZHANG Lin-na, ZHAO Gui-sen. Design and Synthesis of Hydrazine and Oxadiazole-containing Derivatives of Sorafenib as Antitumor Agents[J]. Chemical Research in Chinese Universities, 2013, 29(3): 454-459.

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Design and Synthesis of Hydrazine and Oxadiazole-containing Derivatives of Sorafenib as Antitumor Agents

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