Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (3): 487-494.doi: 10.1007/s40242-013-2294-5

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Synthesis of Novel 3-Aryl Isoindolinone Derivatives

HU Chen-ming, ZHENG Lian-you, PEI Ya-zhong, BAI Xu   

  1. Center for Combinatorial Chemistry and Drug Discovery, College of Chemistry and School of Pharmaceutical Sciences, Jilin University, Changchun 130021, P. R. China
  • Received:2012-08-06 Revised:2012-09-24 Online:2013-06-01 Published:2013-05-15
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.81072526) and the Fund of the Department of Science and Technology of Jilin Province of China(No.20106039).

Abstract:

A library of novel 3-aryl isoindolinone derivatives with aromatic amino acid derivative fragments was designed and synthesized. Two synthetic routes were employed to construct 3-aryl isoindolinone ring system for different amino acid derivatives.

Key words: Molecular library, 3-Aryl isoindolinone, Aromatic amino acid derivative