Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (2): 225-229 .

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Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst

XIE Xiao-na^1,2, ZHANG Chun-li³, XUN Er-na², WANG Jia-xin², ZHANG Hong², WANG Lei², WANG Zhi²

1. The First Hospital of Jilin University, Changchun 130021, P. R. China;
2. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130012, P. R. China;
3. College of Physical Education, Jilin University, Changchun 130012, P. R. China

Received:2011-08-29 Revised:2011-10-10 Online:2012-03-25 Published:2012-03-08
Supported by:
Supported by the National Natural Science Foundation of China(Nos.31070708, 21172093 and 20772046) and the Natural Science Foundation of Jilin Province, China(No.201115038).

Abstract

Abstract: The regioselective acylation of quercetin catalyzed by a novel thermophilic esterase(APE1547) from the archaeon Aeropyrum pernix K1 was successfully conducted in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 74% for its mono ester could be achieved in the reaction for about 6 h. With the reaction time extending to about 30 h, the final conversion of quercetin was about 100% and three products were synthesized.

Key words: Quercetin, Vinyl acetate, APE1547, Acylation

XIE Xiao-na, ZHANG Chun-li, XUN Er-na, WANG Jia-xin, ZHANG Hong, WANG Lei, WANG Zhi. Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst[J]. Chemical Research in Chinese Universities, 2012, 28(2): 225-229 .

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Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst

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