CRCU

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (4): 614-618.

• Articles • Previous Articles     Next Articles

Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(I)

MI Hao-yu1, CUI Lin-lin1, ZHANG Qun-li1, LI Fang2, JIANG Tao2, LIANG Yong-tao1* and WANG En-si1,2*   

  1. 1. College of Life Science, Jilin University, Changchun 130012, P. R. China;
    2. School of Pharmacy, Jilin University, Changchun 130021, P. R. China
  • Received:2010-06-17 Revised:2010-12-28 Online:2011-07-25 Published:2011-06-29
  • Contact: LIANG Yong-tao;WANG En-si1 E-mail:liangyongtao2005@126.com;wangss@jlu.edu.cn
  • Supported by:

    Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co. Ltd.

PDF (PC)

Abstract: A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes. The structures were confirmed by means of 1H NMR, 13C NMR, IR and MS. Most of the compounds display moderate to potent inhibitory activity. Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.

Key words: Immunosuppressant, Amino alcohol derivative, Bucherer-Bergs reaction