Catechu Inhibiting Cathepsin B Activity and Motility of HT1080 Cells

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (2): 269-272.

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Catechu Inhibiting Cathepsin B Activity and Motility of HT1080 Cells

YUAN Hao¹, YANG Jin-gang¹, WANG Zhong-yuan¹, ZHAO Shu-hua², YU Da-hai¹ and FANG Xue-xun^1*

1. Key Laboratory of Molecular Enzymology and Engineering, Ministry of Education, College of Life Science, Jilin University, Changchun 130012, P. R. China;
2. Department of Traditional Chinese Medicine, China-Japan Union Hospital of Jilin University, Changchun 130041, P. R. China

Received:2010-05-06 Revised:2010-08-20 Online:2011-03-25 Published:2011-03-09
Contact: FANG Xue-xun E-mail:fangxx@jlu.edu.cn
Supported by:
Supported by the Program for New Century Excellent Talents from the Ministry of Education of China(No.NCET-08-0244) and the Science and Technology Support Program of Jilin Province, China(No.20090929).

Abstract

Abstract: We reported that Catechu extract has a significant inhibitory effect on cathepsin B activity. The IC50 value for the Catechu extract against cathepsin B was 7.6 ?g/mL. In addition, we showed that HT1080 human fibrosarcoma cells express cathepsin B and Catechu modulate the invasion and motility of these cells. These data may provide molecular mechanisms for the therapeutic effects of Catechu.

Key words: Cathepsin B, Traditional Chinese medicine, Catechu, Tumor, Cell invasion, Cell motility

YUAN Hao, YANG Jin-gang, WANG Zhong-yuan, ZHAO Shu-hua, YU Da-hai, .... Catechu Inhibiting Cathepsin B Activity and Motility of HT1080 Cells[J]. Chemical Research in Chinese Universities, 2011, 27(2): 269-272.

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Catechu Inhibiting Cathepsin B Activity and Motility of HT1080 Cells

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