CXCR4 Peptide Conjugated Au-Fe2O3Nanoparticles for Tumor-targeting Magnetic Resonance Imaging

doi:10.1007/s40242-018-8010-8

Chemical Research in Chinese Universities ›› 2018, Vol. 34 ›› Issue (4): 584-589.doi: 10.1007/s40242-018-8010-8

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CXCR4 Peptide Conjugated Au-Fe₂O₃Nanoparticles for Tumor-targeting Magnetic Resonance Imaging

LIU Guifeng¹, CHEN Hongda², YU Shaonan¹, LI Xiaodong³, WANG Zhenxin²

1. Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;
2. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China;
3. Department of Radiology, the First Hospital of Jilin University, Changchun 130021, P. R. China

Received:2018-01-10 Online:2018-08-01 Published:2018-05-21
Contact: WANG Zhenxin E-mail:wangzx@ciac.ac.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.80151459).

Abstract

Abstract: Peptide-functionalized Au-Fe₂O₃ nanoparticles(termed as anti-CXCR4-Au-Fe₂O₃NPs) have been constructed through conjugation of dumbbell-like Au-Fe₂O₃NPs with C-X-C motif chemokine receptor 4(CXCR4) binding cyclic peptide. One dumbbell-like Au-Fe₂O₃NP composes an Au NP[(3.3±0.3) nm in diameter] for conjuga-ting CXCR4 binding cyclic peptide through Au-S covalent bond and a Fe₂O₃NP[(8.7±0.8) nm in diameter] for using as T₂-weighted magnetic resonance imaging(MRI) contrast agent. The anti-CXCR4-Au-Fe₂O₃NPs have reasonable biocompatibility and integration of T₂-weighted MRI contrast and tumor-targeting functionalities. The anti-CXCR4-Au-Fe₂O₃NPs exhibit strong interactions with two kinds of breast tumor cells, MCF-7 cells and MDA-MB-231 cells, and high negative contrast in MRI of MDA-MB-231 tumor bearing mouse with 62% decreasing of MRI signal, indicating that the anti-CXCR4-Au-Fe₂O₃NPs can recognize tumor with high efficacy and specificity.

Key words: Dumbbell-like Au-Fe₂O₃ nanoparticle, C-X-C motif chemokine receptor 4, Cyclic peptide, T₂-Weighted magnetic resonance imaging, Tumor targeting ability

LIU Guifeng, CHEN Hongda, YU Shaonan, LI Xiaodong, WANG Zhenxin. CXCR4 Peptide Conjugated Au-Fe₂O₃Nanoparticles for Tumor-targeting Magnetic Resonance Imaging[J]. Chemical Research in Chinese Universities, 2018, 34(4): 584-589.

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CXCR4 Peptide Conjugated Au-Fe₂O₃Nanoparticles for Tumor-targeting Magnetic Resonance Imaging

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