Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (2): 217-220.

• Articles • Previous Articles     Next Articles

Isolation and Identification of Two New Polyhydroxylated Sterols from Soft Coral Sinularia sp.

LIAO Xiao-jian, TANG Li-dan, LIANG Yuan-wei, GENG Hua-wei and XU Shi-hai*   

  1. Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China
  • Received:2010-06-23 Revised:2010-10-13 Online:2011-03-25 Published:2011-03-09
  • Contact: XU Shi-hai E-mail:txush@jnu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20772048).

Abstract: Two new polyhydroxysteroids, 12β,16β,20-trihydroxycholesta-1,4-dien-3-one 16-acetate(1) and 24-  methyl-12β,16β,20-trihydroxycholesta-1,4-dien-3-one(2) were isolated from octocoral Sinularia sp. Their structures were elucidated primarily on the basis of 1D and 2D NMR and the mass spectroscopic studies. The cytotoxicity of these compounds against three tumor cell lines was also reported.

Key words: Sinularia sp., Polyhydroxysteroid, Cytotoxic activity