Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (5): 753-757.doi: 10.1007/s40242-017-7061-6

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Two New Baccharane Glycosides from Seeds of Impatientis balsamina L. with in vitro Growth Inhibitory Activity in Human Cancer A375 Cells

WU Qian1, JIN Yongri1, YAO Hua2, LIU Ying1, LI Peng1, LI Xuwen1   

  1. 1. College of Chemistry, Jilin University, Changchun 130021, P. R. China;
    2. Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130021, P. R. China
  • Received:2017-02-22 Revised:2017-07-04 Online:2017-10-01 Published:2017-08-07
  • Contact: LI Xuwen,E-mail:xwli@jlu.edu.cn E-mail:xwli@jlu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.81173602).

Abstract:

Two new baccharane-type glycosides(1 and 2), together with seven known baccharane-type glycosides(3-9) hosenkoside A, hosenkoside B, hosenkoside C, hosenkoside F, hosenkoside M, hosenkoside K and hosenkoside G were isolated from the dried seeds of Impatientis balsamina L. The new baccharane-type glycosides were identified as honsenkol A-3-O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl-O-β-Dglucopyranosyl(1) and (3S,4R,17R,20S)-17-hydroxy-3-O-β-D-xylopyranose(12)-β-D-glucopyranosyl-26-O-β-Dglucopyranosyl-28-O-β-D-glucopyranosyl-21,24-epoxybaccharane(2), respectively, by spectroscopic methods, including NMR(1D and 2D), IR and HR-ESI-MS. Compounds 1 and 2 were evaluated for in vitro inhibitory activity against the cell lines. Compound 2 with a new baccharane skeleton had anti-hepatic fibrosis activity against A375 cells in bioassay results, which means the new compounds have potential value in antitumor applications.

Key words: Impatientis balsamina L., Seed, Baccharane-type glycoside, Cytotoxic activity