CRCU

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (1): 80-82.

• Articles • Previous Articles     Next Articles

Association of Matrix Metalloproteinase-9 and p53 Gene Polymorphisms with Genetic Susceptibility to No-small-cell Lung Cancer

ZHAO Ying-hao1, MA Tong-hui2, ZHENG Yong-chen2, ZHANG Kun2, YANG Jing-bo2, YANG Long-fei2, YANG Zhi-guang1 and SHAO Guo-guang1*   

  1. 1. Department of Thoracic Surgery,
    2. Central Research Laboratory, The Second Hospital of Jilin University, Changchun 130041, P. R. China
  • Received:2010-09-02 Revised:2010-11-04 Online:2011-01-25 Published:2011-01-04
  • Contact: SHAO Guo-guang E-mail:thoracicresearch@gmail.com

PDF (PC)

Cited

3

Abstract: Matrix metalloproteinase-9(MMP-9) and p53 genes play an essential role in the multi-step process of tumorigenesis in lung cancer. Single nucleotide polymorphisms(SNPs) of MMP-9 and p53 genes are associated with the risk and progression of many cancers. In this study, we evaluated the association of the R279Q polymorphism of MMP-9 or the A1/A2 polymorphism of p53 gene with the risk of no-small-cell lung cancer(NSCLC) in Han population of Northeast China. We examined the frequency of SNPs in the two kinds of genes of 50 patients with NSCLC and 50 cancer-free controls frequency-matched by age and sex. Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was used to determine the genotypes. The results indicate that the 279RR genotype in MMP-9 gene and the A1/A2 genotype in p53 gene show a significantly increased risk of NSCLC. Therefore, the MMP-9 279RR and p53 A1/A2 genotypes may be used as markers for susceptibility to NSCLC in Han population of Northeast China.

Key words: Single nucleotide polymorphisms(SNPs), No-small-cell lung cancer(NSCLC), Matrix metalloproteinase- 9(MMP-9), p53, Susceptibility