Chemical Research in Chinese Universities ›› 2010, Vol. 26 ›› Issue (2): 204-209.

• Articles • Previous Articles     Next Articles

Effects of Nitrobenzene on Liver Antioxidant Defense System of Carassius auratus

SHAO Peng1,2, YUAN Xing1*, LIU Rui2* and CAO Jian-ping1   

  1. 1. College of Urban and Environmental Science, Northeast Normal University, Changchun 130024, P. R. China;
    2. Research Institute of Environment, Yangtze Delta Institute of Tsinghua University, Jiaxing 314006, P. R. China
  • Received:2009-08-04 Revised:2009-09-07 Online:2010-03-25 Published:2010-05-25
  • Contact: YUAN Xing. E-mail: yuanx@nenu.edu.cn; LIU Rui. E-mail: liuruitsinghuazj@gmail.com
  • Supported by:

    Supported by the National Key Technologies Research & Development Program of China(No.2006BAC02A16-2) and the Science and Technology Department Major Programs Project of Jilin Province, China(No.20065021).

Abstract:

With superoxidedismutase(SOD), catalase(CAT), glutathione S-transferase(GST) and malondialdehyde (MDA) as characteristic indexes, the effects of nitrobenzene(NB) on the liver antioxidant defense system of Carassius auratus were studied under the indoors stimulant conditions, and the toxic mechanisms were discussed. The exposure concentrations of NB were 0.5, 1.0, 5.0 and 10.0 mg/L, and the exposure time was 5, 10 and 15 days, respectively. The results show that the stress responses of four antioxidant indexes in the fish liver to nitrobenzene were different. The SOD activity was firstly inhibited and then induced. The CAT and GST activities were mainly induced. The MDA content in the high concentration group showed a significant time-effect relationship. In addition, the changes of CAT and SOD activities were not synchronous, and GST played an important part in the detoxification process of nitrobenzene.

Key words: Nitrobenzene; Superoxide dismutase; Catalase; Glutathione S-transferase; Malondialdehyde