CRCU

Chemical Research in Chinese Universities ›› 2005, Vol. 21 ›› Issue (5): 512-516.

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Synthesis of Nonionic Oligomeric Manganese(Ⅱ) Complexes and Investigation of Their Toxicity and T1-Relaxation Enhancement

YU Kai-chao1,2, LI Ying-xia1, ZHOU Jin-lan2, DING Shang-wu1,3, YE Chao-hui1   

  1. 1. State Key Laboratory of Magnetic Resonance & Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, P. R. China;
    2. Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P. R. China;
    3. Department of Chemistry and Center for Nano Science & Nano Technology, National Sun Yat-Sen University, Kaohsiung, 80424 Taiwan, China
  • Received:2004-11-23 Online:2005-09-23 Published:2011-08-06
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.20275011 and 10234070), the Program for Promoting University Academic Excellence by the Ministry of Education of Taiwan of China(No.A-92-N-FA01-2-4-5) and Foundation of State Key Laboratory of Magnetic Resonance & Atomic and Molecular Physics(No.T12045).

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Abstract: Six nonionic oligomeric manganese(Ⅱ) complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn(Ⅱ) complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.

Key words: Magnetic resonance imaging(MRI), Oligomeric contrast agent, Nonionic Mn(Ⅱ) complex, Relaxivity, Acute toxicity, Relaxation enhancement