CRCU

Chemical Research in Chinese Universities ›› 2003, Vol. 19 ›› Issue (4): 386-389.

• Articles • Previous Articles     Next Articles

Studies of Active Ingredients in Cough Syrup by Capillary Zone Electrophoresis with Amperometric Detection

ZHOU Tian-shu1, WANG Ai-fang2, WU Fang2, SHI Guo-yue2, FANG Yu-zhi2   

  1. 1. Department of Environmental Science, East China Normal University, Shanghai 200062, China;
    2. Department of Chemistry, East China Normal University, Shanghai 200062, China
  • Received:2002-09-25 Online:2003-12-24 Published:2011-08-06
  • Supported by:

    Supported by the Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry of Chinese Academy of Sciences.

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Abstract: The present paper covers a simple, reliable and reproducible method, based on capillary zone electrophoresis(CZE) with amperometric detection(AD), for the separation and the determination of ephedrine hydrochloride, promethazine hydrochloride and codeine phosphate. Under the optimal conditions, the three analytes were base-line separated completely within 16 min. Good linear relationships between the peak heights and the concentrations of the three analytes were obtained with the correlation coefficients better than 0.9993. The method was directly applied to the determination of the active ingredients in pharmaceutical preparations and the assay results were satisfactory.

Key words: Capillary zone electrophoresis, Amperometric detection, Ephedrine hydrochloride, Promethazine hydrochloride, Codeine phosphate