Chemical Research in Chinese Universities ›› 2002, Vol. 18 ›› Issue (2): 146-152.

• Articles • Previous Articles     Next Articles

Facile Syntheses of (6S)-6-Fluoroshikimic Acid and (6R)-6-Hydroxyshikimic Acid

Chuanjun Song1,2, Shende Jiang1, Gurdial Singh1   

  1. 1. Department of Chemistry, University of Sunderland, Sunderland, SR1 3SD, UK;
    2. Department of Applied Chemistry, Tianjin University, Tianjin 300072, P. R. China
  • Received:2001-12-12 Online:2002-04-24 Published:2011-08-04

Abstract: (6S)-6-Fluoroshikimic acid 2 and (6R)-6-hydroxyshikimic acid 3 have been synthesized via an OsO4-catal-ysed dihydroxylation of diene 7, which was derived from (-)-shikimic acid 1.

Key words: Shikimate pathway, Shikimic acid, Fluoroshikimic acid, Dihydroxylation, Fluorination