Abstract: In a 0.10 mol/L Hac-NaAc buffer solution(pH= 4.59), a sensitive reduction peak of bleomycin was observed by linear sweep voltammetry at a Co/GC ion implantation modified electrode.The peak potential was -0.73 V(vs.SCE).The peak current was proportional to the concentration of bleomycin over the range of 5.0 × 10^-8-1.0 × 10^-6 and 1.0 × 10^-6-1.0 × 10^-5mol/L with a detection limit of 2.0 × 10^-8 mol/L.The electrochemical behavior of the reduction peak of bleomycin at the Co/GC modified electrode was studied by linear sweep and cyclic voltammetry and applied to the determination of bleomycin in urine.This method is simple,rapid and reliable.The reduction process is quasi-reversible.The experiments of AES and XPS showed that Co was surely implanted into the surface of GCE and the depth distribution of Co was ingood agreement with Gooses normal distribution; the implanted Co at GCE improved the electrocatalytic activity.

Key words: Co/GC ion implantation modified electrode, Electrochemical behavior, Linear sweep voltammetry, Bleomycin