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Chemical Research in Chinese Universities ›› 1999, Vol. 15 ›› Issue (2): 128-133.

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Studies on the Voltammetric Behavior of Nicardipine Hydrochloride, its Voltammetric Determination at the Co/GC Modified Electrode

ZHI Yao1, HU Jing-bo1, LI Qi-long1, HUANG Qing-quan2   

  1. 1. Department of Chemistry, Beijing Normal University, Beijing, 100875;
    2. National Institute for the Control of Pharmaceutical, Biological Products, Beijing, 100050
  • Received:1998-10-17 Online:1999-04-24 Published:2011-08-17
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.29475189).

PDF (PC)

Abstract: To whom correspondence should be addressed. In a 0.02 mol/L BR buffer solution(pH=5.52), the electrochemical behaviour of nicardipine hydrochloride was studied by linearsweep voltammetry, cyclic voltammetry at a Co/GC ion implantation modified electrode. The experiments showed that the electrode had a good stability, reproductivity. The peak height was proportional to the concentration of nicardipine over the range of 4.0×10-7—1.0×10-4 mol/L, the detection limit was 1.0×10-7 mol/L. This method has been used for the direct determination of nicardipine in tablets. Its recoveries were in the range from 95.6% to 103.8%. The reduction of nicardipine at the Co/GC electrode was an irreversible proccess.

Key words: Ion implantation, Modified electrode, Nicardipine, Linear-sweep voltammetry