CRCU

Chemical Research in Chinese Universities ›› 1999, Vol. 15 ›› Issue (2): 116-121.

• Articles • Previous Articles     Next Articles

Cleavage of Nucleotides by Lanthanide Metal Complexes

ZHU Bing, ZHAO Da-qing, Ni Jia-zuan   

  1. Laboratory of Rare Earth Chemistry, Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, 130022
  • Received:1998-04-27 Online:1999-04-24 Published:2011-08-17
  • Supported by:

    Supported by the National Program "The National Natural Science Foundation of China and The Basic Research of Rare Earth Science of China".

PDF (PC)

Cited

5

Abstract: The present work revealed that the praseodymium(Ⅲ) complex of 2-carboxyethylgermanium sesquioxide(Ge-132) promotes the hydrolysis of the phosphodiester linkages of 3',5'-cyclic adenosine monophosphate(cAMP), 3',5'-cyclic deoxyadenosine monophosphate(dcAMP), 5'-adenosine monophosphate(5'-AMP), 5'-deoxyadenosine monophosphate(5'-dAMP) under mild conditions. Both cAMP, dcAMP were hydrolyzed sitespecifically, yielding predominantly 3'-monophosphates, the main products of the cleavage of 5'-AMP, 5'-dAMP included adenosine(Ado), deoxyadenosine(dAdo), free phosphates respectively. A hydrolytic mechanism was proposed for cAMP, dcAMP, 5'-AMP, 5'-dAMP.

Key words: Lanthanide metal(Ⅲ) complexes, Nucleotides cleavage, Artificial nucleases