Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis

doi:10.1007/s40242-024-4146-x

Chemical Research in Chinese Universities ›› 2025, Vol. 41 ›› Issue (1): 86-94.doi: 10.1007/s40242-024-4146-x

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Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis

LI Tingting^1,2,3, JIA Mengni^2,3, JI Huifang^2,3, ZHANG Ruiping⁴

1. The Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, P. R. China;
2. Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, P. R. China;
3. School of Pharmacy, Shanxi Medical University, Taiyuan 030001, P. R. China;
4. The Radiology Department of Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, P. R. China

Received:2024-06-19 Online:2025-02-01 Published:2025-01-18
Contact: LI Tingting,litingting@sxmu.edu.cn;ZHANG Ruiping,zrp_7142@sxmu.edu.cn E-mail:litingting@sxmu.edu.cn;zrp_7142@sxmu.edu.cn
Supported by:
This work was supported by the Project of the Key Laboratory of Nano-imaging and Drug-loaded Preparation of Shanxi Province, China (No. 202104010910010), the Project Funded by China Postdoctoral Science Foundation (No. 2022M722001), the Natural Science Foundation for Shanxi Province, China (No. 202103021224241) and the Special Fund from Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, China (No. CKD/SXMU-2024-11).

Abstract

Abstract: In this work, melanin nanoparticle-resveratrol (MNP-RES) nanosystem was excogitated and constructed for the treatment and imaging of folate-induced renal fibrosis (RF) mice model to fulfill the combination of diagnosis and therapeutic. Physicochemical characterization indicated that MNP-RES was a monodisperse spherical framework with a uniform diameter of (18.6±2.7) nm and the drug loading content of RES was 44.8%. The inhibition ratios of reactive oxygen species, such as ^·OH,^·O₂^-, ABTS^· and DPPH were all greater than 80%. After systemic therapy with MNP-RES, the levels of serum creatinine (SCr) and blood urea nitrogen (BUN) were decreased, and the extent of renal fibrosis was considerably relieved, which was verified by H&E, Masson and terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) staining. The MNP-RES nanosystem can diagnose and monitor the therapeutic efficacy of RF in real time and noninvasively via photoacoustic/magnetic resonance imaging (PA/MRI) dual-modality imaging, and the MNP-RES diagnostic-therapeutic nanosystem had satisfactory biocompatibility in vivo, which facilitated its future bio-transformation for RF treatment in clinical application.

Key words: Melanin, Resveratrol, Diagnostic-therapeutic nanosystem, Dual-modal imaging, Renal fibrosis

LI Tingting, JIA Mengni, JI Huifang, ZHANG Ruiping. Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis[J]. Chemical Research in Chinese Universities, 2025, 41(1): 86-94.

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Integration of Melanin-Resveratrol Nanosystem for the Diagnostic-therapeutic of Renal Fibrosis

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