ICG and Sunitinib-loaded NH2-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy

doi:10.1007/s40242-021-1206-3

Abstract

Abstract: This research investigated a novel folic acid(FA)-modified zirconium core metal-organic framework(MOF) Uio-66 as a nanocarrier to deliver indocyanine green(ICG) and Sunitinib to cancer cells for combination therapy. Platinum-loaded Uio-66 nanoparticles(Pu) were synthesized via a one-pot method, followed by the modification with FA on their surfaces. This afforded FPu that enabled subsequent loading of ICG and Sunitinib to achieve dual-modal cancer therapy. Drug loading/release test and singlet oxygen detection were also conducted in vitro, and the nanoparticles showed considerable drug loading efficiency for both ICG and Sunitinib, coupled with a high singlet oxygen generation rate. Specifically, drug loading and encapsulation efficiency of Sunitinib were 2.30% and 72.67%, while those for ICG were 2.87% and 90.28%, respectively. Additionally, cytotoxicity test on HepG2 human hepatocellular carcinoma cancer cell line revealed that the fully functional nanoparticles possess excellent biocompatibility and as such could be further investigated as a potential drug delivery system for effectual carcinoma cancer treatment.

Key words: Metal organic framework, Uio-66, Indocyanine green, Sunitinib, Hepatocellular carcinoma

ZHANG Zhoujing, LIU Chuang, Ozioma AKAKURU, XU Wenjing, WU Aiguo, ZHANG Yewei. ICG and Sunitinib-loaded NH₂-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy[J]. Chemical Research in Chinese Universities, 2021, 37(4): 967-974.

References

[1] Finn R. S., Zhu A.X., Hepatology, 2021, 73, 150
[2] https://www.iarc.who.int/faq/latest-global-cancer-data-2020-qa/Accessed on 2021-04-26
[3] Lee H. A., Park S., Seo Y. S., Yoon W. S., Shin I. S., Rim C. H., J. Hepatobiliary Pancreat Sci., Epub Ahead of print, PMID:33179421
[4] McGlynn K. A., Petrick J. L., El-Serag H. B., Hepatology, 2021, 73, 4
[5] Huang A., Yang X. R., Chung W. Y., Dennison A. R., Zhou J., Signal Transduct Target Ther., 2020, 5, 146
[6] Zhu A. X., Sahani D. V., Duda D. G., di Tomaso E., Ancukiewicz M., Catalano O. A., Sindhwani V., Blaszkowsky L. S., Yoon S. S., Lahdenranta J., Bhargava P., Meyerhardt J., Clark J. W., Kwak E. L., Hezel A. F., Miksad R., Abrams T. A., Enzinger P. C., Fuchs C. S., Ryan D. P., Jain R. K., J. Clin. Oncol., 2009, 27, 3027
[7] Polom K., Murawa D., Rho Y. S., Nowaczyk P., Hünerbein M., Murawa P., Cancer, 2011, 117(21), 4812
[8] Baj J., Sitarz R., Łokaj M., Forma A., Czeczelewski M., Maani A., Garruti G., Molecules, 2020, 25(7), 1724
[9] Zhang X., Li Y., Wei M., Liu C., Yu T., Yang J., Drug Deliv., 2019, 26(1), 129
[10] Wang Y., Xie Y., Li J., Peng Z. H., Sheinin Y., Zhou J., Oupický D., ACS Nano, 2017, 11(2), 2227
[11] Yu Z., Xiao Z., Shuai X., Tian J., J. Mater. Chem. B, 2020, 8(30), 6418
[12] Desmettre T., Devoisselle J. M., Mordon S., SurvOphthalmol, 2000, 45(1), 15
[13] Santos J. H., Quimque M. T. J., Macabeo A. P. G., Corpuz M. J. T., Wang Y. M., Lu T. T., Lin C. H., Villaflores O. B., Pharmaceutics, 2020, 12(5), 437
[14] Jarai B. M., Stillman Z., Attia L., Decker G. E., Bloch E. D., Fromen C. A., ACS Appl Mater Interfaces, 2020, 12(35), 38989
[15] Liu C., Luo L., Zeng L., Xing J., Xia Y., Sun S., Zhang L., Yu Z., Yao J., Yu Z., Akakuru O. U., Saeed M., Wu A., Small, 2018, 14(35), e1801851
[16] Ogiwara N., Kobayashi H., Concepción P., Rey F., Kitagawa H., Angew. Chem. Int. Ed. Engl., 2019, 58(34), 11731
[17] Zhang W., Ji W., Li L., Qin P., Khalil I. E., Gu Z., Wang P., Li H., Fan Y., Ren Z., Shen Y., Zhang W., Fu Y., Huo F., ACS Appl. Mater. Interfaces, 2020, 12(47), 52660
[18] Chen S. S., Hu C., Liu C. H., Chen Y. H., Ahamad T., Alshehri S. M., Huang P. H., Wu K. C., J. Hazard Mater., 2020, 397, 122431
[19] Dong H., Yang G. X., Zhang X., Meng X. B., Sheng J. L., Sun X. J., Feng Y. J., Zhang F. M., Chemistry, 2018, 24(64), 17148
[20] Gao X., Cui R., Ji G., Liu Z., Nanoscale, 2018, 10(13), 6205
[21] Dong H., Yang G. X., Zhang X., Meng X. B., Sheng J. L., Sun X. J., Feng Y. J., Zhang F. M., Chemistry, 2018, 24(64), 17148
[22] Liu M. C., Liu L., Wang X. R., Shuai W. P., Hu Y., Han M., Gao J. Q., Int. J. Nanomedicine, 2016, 11, 1395
[23] Koirala N., Das D., Fayazzadeh E., Sen S., McClain A., Puskas J. E., Drazba J. A., McLennan G., J. Biomed. Mater. Res. A, 2019, 107(11), 2522
[24] Kulkarni T. A., Bade A. N., Sillman B., Shetty B. L. D., Wojtkiewicz M. S., Gautam N., Hilaire J. R., Sravanam S., Szlachetka A., Lamberty B. G., Morsey B. M., Fox H. S., Alnouti Y., McMillan J. M., Mosley R. L., Meza J., Domanico P. L., Yue T. Y., Moore G., Edagwa B. J., Gendelman H. E., Nat. Mater., 2020, 19(8), 910
[25] Unciti-Broceta J. D., Arias J. L., Maceira J., Soriano M., Ortiz-González M., Hernández-Quero J., Muñóz-Torres M., de Koning H. P., Magez S., Garcia-Salcedo J. A., PLoSPathog, 2015, 11(6), e1004942
[26] Cassidy L. D., Young A. R., Pérez-Mancera P. A., Nimmervoll B., Jaulim A., Chen H. C., McIntyre D. J. O., Brais R., Ricketts T., Pacey S., De La Roche M., Gilbertson R. J., Rubinsztein D. C., Narita M., Autophagy, 2018, 14(7), 1256
[27] Singletary M., Lau J. W., Hagerty S., Pustovyy O., Globa L., Vodyanoy V., Sci. Rep., 2020, 10(1), 18435
[28] Rojas S., Colinet I., Cunha D., Hidalgo T., Salles F., Serre C., Guillou N., Horcajada P., ACS Omega., 2018, 3(3), 2994
[29] Tabatabaeian K., Simayee M., Fallah-Shojaie A., Mashayekhi F., Daru., 2019, 27(1), 307
[30] Farboudi A., Mahboobnia K., Chogan F., Karimi M., Askari A., Banihashem S., Davaran S., Int. J. Biol. Macromol., 2020, 150, 178
[31] van Dam G. M., Themelis G., Crane L. M., Harlaar N. J., Pleijhuis R. G., Kelder W., Sarantopoulos A., de Jong J. S., Arts H. J., van der Zee A. G., Bart J., Low P. S., Ntziachristos V., Nat. Med., 2011, 17(10), 1315
[32] Zhou Y., Unno K., Hyjek E., Liu H., Zimmerman T., Karmakar S., Putt K. S., Shen J., Low P. S., Wickrema A., Leuk Lymphoma, 2018, 59(12), 2982
[33] Kamen B. A., Smith A. K., Adv. Drug Deliv. Rev., 2004, 56(8), 1085
[34] Brown Jones M., Neuper C., Clayton A., Mariani A., Konecny G., Thomas M. B., Keeney G., Hartmann L., Podratz K. C., Int. J. Cancer., 2008, 123(7), 1699
[35] Iwakiri S., Sonobe M., Nagai S., Hirata T., Wada H., Miyahara R., Ann. Surg. Oncol., 2008, 15(3), 889
[36] Liu Y., Yang G., Jin S., Xu L., Zhao C. X., Chempluschem, 2020, 85(9), 2143
[37] Itatani Y., Kawada K., Yamamoto T., Sakai Y., Int. J. Mol. Sci., 2018, 19(4), 1232
[38] Yang Y., Li N., Chen T., Zhang C., Liu L., Qi Y., Bu P., Pharm. Biol., 2019, 57(1), 625
[39] Yang Y., Li N., Chen T., Zhang C., Li J., Liu L., Qi Y., Zheng X., Zhang C., Bu P., Arch. Toxicol., 2019, 93(11), 3249
[40] Zhao Q., Zhang T., Xiao X. R., Huang J. F., Wang Y., Gonzalez F. J., Li F., Br. J. Pharmacol., 2019, 176(13), 2162

ICG and Sunitinib-loaded NH₂-MOFs for Folate-mediated Hepatocellular Carcinoma Dual-modal Therapy

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