Chemical Research in Chinese Universities ›› 2021, Vol. 37 ›› Issue (1): 83-89.doi: 10.1007/s40242-021-0402-5

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Recent Progress in Boosted PDT Induced Immunogenic Cell Death for Tumor Immunotherapy

LI Jun, OU Hanlin, DING Dan   

  1. State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China
  • Received:2020-11-30 Revised:2020-12-24 Online:2021-02-01 Published:2021-02-03
  • Contact: DING Dan E-mail:dingd@nankai.edu.cn
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (Nos.51873092, 51961160730, 31900983), the National Key R&D Program of China(Intergovernmental Cooperation Project, No.2017YFE0132200), the Fundamental Research Funds for the Central Universities of China, and the Tianjin Science Fund for Distinguished Young Scholars, China (No.19JCJQJC61200).

Abstract: With the rapid development of materials science, photosensitive materials have been widely used in the field of immunogenic cell death(ICD), which was on account of the reactive oxygen species(ROS) generation by photosensitizer under light irradiation inducing cellular oxidative stress during the dying of cells. Considerable researches related to photodynamic therapy(PDT) induced ICD were conducted and exhibited brilliant performance in cancer immunotherapy. Herein, a variety of different strategies for PDT induced ICD have been summarized and discussed to provide researchers more inspiration for cancer immunotherapy.

Key words: Photodynamic therapy, Immunogenic cell death, Damage-associated molecular pattern