Synthesis and Characterization of 3-Phenyl-adamantane-1-carboxylic Acid

doi:10.1007/s40242-019-9134-1

Chemical Research in Chinese Universities ›› 2019, Vol. 35 ›› Issue (4): 556-559.doi: 10.1007/s40242-019-9134-1

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Synthesis and Characterization of 3-Phenyl-adamantane-1-carboxylic Acid

FENG Wei¹, YE Kaiqi², JIANG Yang¹, HOU Ruibin³

1. China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;
2. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
3. Advanced Institute of Materials Science, College of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, P. R. China

Received:2019-05-14 Revised:2019-06-20 Online:2019-08-01 Published:2019-08-01
Contact: JIANG Yang E-mail:jiangyang@jlu.edu.cn
Supported by:
Supported by the Medical and Health Project of the Science and Technology Department of Jilin Province, China (No.20190304047YY).

Abstract

Abstract: Adamantane and its derivatives have been introduced into many drugs for current clinical research and some of them are used for the treatment of neurological disease and/or used as the antiviral agents as well as the agents against type-2 diabetes. Recently, there have been many relevant research reported for developing medicinal chemistry by employing the adamantyl group. In this paper, a new adamantane-based compound (3-phenyl-adaman-tane-1-carboxylic acid, PACA) was synthesized and characterized by X-ray diffraction(XRD), thermogravimeric analysis(TGA), Fourier transform infrared spectroscopy(FTIR), etc., which should be a beneficial complement or extension to the existing adamantyl-based materials.

Key words: Adamantane, Cage-like molecule, Medicinal chemistry, Single crystal

FENG Wei, YE Kaiqi, JIANG Yang, HOU Ruibin. Synthesis and Characterization of 3-Phenyl-adamantane-1-carboxylic Acid[J]. Chemical Research in Chinese Universities, 2019, 35(4): 556-559.

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Synthesis and Characterization of 3-Phenyl-adamantane-1-carboxylic Acid

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