Chemical Research in Chinese Universities ›› 2018, Vol. 34 ›› Issue (1): 57-60.doi: 10.1007/s40242-018-7238-7

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Gold-catalyzed Intermolecular Oxidation of Phenylacetylene and Allylic Sulfides: an Efficient and Practical Synthesis of α-Phenylthio Ketone

ZHENG Renhua1, HUANG Qing2, GUOHaichang1, HUANGYidie1, JIANG Huajiang1   

  1. 1. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P. R. China;
    2. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China
  • Received:2017-07-11 Online:2018-02-01 Published:2018-01-20
  • Contact: ZHENG Renhua,E-mail:zhengrh@tzc.edu.cn;JIANG Huajiang,E-mail:jhj@tzc.edu.cn E-mail:zhengrh@tzc.edu.cn;jhj@tzc.edu.cn
  • Supported by:
    Supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China(No.2015-1098).

Abstract: An efficient and practical synthesis of α-phenylthio ketone through gold-catalyzed intermolecular oxidation of phenylacetylene and substituted aryl(benzyl) allylic sulfides was developed. The reaction scope is fairly good with substituted aryl(benzyl) allylic sulfides, tolerating various functional groups, and the reaction affords the yields of 63%—85%.

Key words: Gold-catalyst, α-Phenylthio ketone, Oxidation, Phenylacetylene