CRCU

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (6): 890-894.doi: 10.1007/s40242-017-7129-3

• Articles • Previous Articles     Next Articles

Total Synthesis and Biological Evaluation of Wewakazole

LONG Bohua1,2,3, ZHANG Jingzhao4, WANG Xueyan4, TANG Xudong4, WU Zhengzhi1,2,3   

  1. 1. The Fourth People's Hospital of Shenzhen, Shenzhen 518033, P. R. China;
    2. Shenzhen Institute of Geriatrics, Shenzhen 518020, P. R. China;
    3. The Second People's Hospital of Shenzhen, Shenzhen 518035, P. R. China;
    4. Key Lab for New Drug Research of TCM and Shenzhen Branch, State R & amp;D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, P. R. China
  • Received:2017-04-05 Revised:2017-05-25 Online:2017-12-01 Published:2017-09-26
  • Contact: LONG Bohua,E-mail:bhlong121@163.com E-mail:bhlong121@163.com
  • Supported by:
    Support by the Health and Family Planning Commission of Shenzhen Municipality, China(No.201601053) and the Basic Research Project of Shenzhen Science and Technology Plan, China(No.JCYJ20160428110124165).

Abstract: The total synthesis of Wewakazole was achieved on a gram scale, unambiguously confirming its structure. Three different substituted oxazoles present in this natural product were prepared efficiently. Biological evaluation indicated that Wewakazole significantly inhibited cancer cell proliferation in a dose-dependent manner.

Key words: Wewakazole, Total synthesis, Biological evaluation