Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like Ligand and Bismuth(Ⅲ) Nitrate

doi:10.1007/s40242-016-5350-0

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (2): 207-211.doi: 10.1007/s40242-016-5350-0

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Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like Ligand and Bismuth(Ⅲ) Nitrate

LI Chuanhua¹, JIANG Jianhong¹, LI Xu¹, XIAO Shengxiong¹, WEI Deliang¹, JIANG Chao¹, XIE Jinqi¹, PENG Mengna¹, GU Huiwen², LI Qiangguo¹

1. Hunan Provincial Key Laboratory of Xiangnan Rare-precious Metals Compounds and Applications, Department of Chemistry and Life Science, Xiangnan University, Chenzhou 423000, P. R. China;
2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

Received:2015-09-10 Revised:2015-10-20 Online:2016-04-01 Published:2015-12-14
Contact: GU Huiwen, LI Qiangguo E-mail:liqiangguo@163.com;gruyclewee@hnu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21273190, 20973145) and the Science and Technology Plan Projects of Hunan Province, China(Nos.2014FJ3011, 2013FJ3033, 2014TT2026).

Abstract

Abstract:

In this paper, a novel bismuthoxide Schiff-base complex [Bi₉O₈(vanen)₃(NO₃)₂(CH₃OH)₂(H₂O)·3NO₃·5.5H₂O](abbreviated as Bivanen) was synthesized with Salen-like ligand H₂vanen[H₂vanen=N,N'-ethylene bis(3-methoxysalicylideneimine)] and bismuth(Ⅲ) nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaccharomyces pombe(S. pombe) were studied using biological microcalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant(k), inhibition ratio(I) and half inhibition concentration(IC₅₀) were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC₅₀ of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.

Key words: Bismuthoxide Schiff-base complex, Microcalorimetriy, Thermokinetic property, Schizosaccharomyces pombe(S. pombe)

LI Chuanhua, JIANG Jianhong, LI Xu, XIAO Shengxiong, WEI Deliang, JIANG Chao, XIE Jinqi, PENG Mengna, GU Huiwen, LI Qiangguo. Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like Ligand and Bismuth(Ⅲ) Nitrate[J]. Chemical Research in Chinese Universities, 2016, 32(2): 207-211.

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Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like Ligand and Bismuth(Ⅲ) Nitrate

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