Preparation and Investigation of Arsenic Trioxide-loaded Polylactic Acid/Magnetic Hybrid Nanoparticles

doi:10.1007/s40242-014-3306-9

Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (2): 326-332.doi: 10.1007/s40242-014-3306-9

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Preparation and Investigation of Arsenic Trioxide-loaded Polylactic Acid/Magnetic Hybrid Nanoparticles

SONG Xiaoli, YOU Juan, WANG Juan, ZHU Aiping, JI Lijun, GUO Rong

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China

Received:2013-07-17 Revised:2013-10-29 Online:2014-04-01 Published:2013-11-25
Contact: SONG Xiaoli E-mail:xlsong@yzu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21201149, 51273171), the Natural Science Foundation of Jiangsu Province, China(No.BK2012259), the Jiangsu College Graduate Research and Innovation Programs, China (No.CXLX12_0914), the Project of the Testing Center of Yangzhou University(China) and the Priority Academic Program Development of Jiangsu Higher Education Institutions(China).

Abstract

Abstract:

In order to improve the therapeutic index and reduce the side effects of As₂O₃ so as to expand its clinical utility to solid tumors, As₂O₃-loaded polylactic acid(PLA)/magnetic nanoparticles(PAMNs) were prepared and the preparation conditions were optimized by the improved double emulsion solvent-evaporation method to obtain as a drug delivery system with a high As₂O₃ encapsulation efficiency and homogeneous nanosized particles. Successful loading of magnetic nanoparticles into the nanoparticles was confirmed by Fourier transform infrared(FTIR) spectroscopy. The drug loading, encapsulation efficiency and releasing properties of As₂O₃ in PAMNs were investigated by atomic fluorescence spectrometer analysis. Subsequently, the in vitro antitumor efficacy of free As₂O₃and As₂O₃-PAMNs against SMMC-7721 cell line was investigated. Finally, confocal fluorescence microscopy was conducted to reveal the celluar uptake of As₂O₃-loaded PAMNs by SMMC-7721 cell line.

Key words: As₂O₃, Magnetism, Polylactic acid nanoparticle, Drug release

SONG Xiaoli, YOU Juan, WANG Juan, ZHU Aiping, JI Lijun, GUO Rong. Preparation and Investigation of Arsenic Trioxide-loaded Polylactic Acid/Magnetic Hybrid Nanoparticles[J]. Chemical Research in Chinese Universities, 2014, 30(2): 326-332.

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Preparation and Investigation of Arsenic Trioxide-loaded Polylactic Acid/Magnetic Hybrid Nanoparticles

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