Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole

doi:10.1007/s40242-017-7108-8

高等学校化学研究 ›› 2017, Vol. 33 ›› Issue (6): 864-868.doi: 10.1007/s40242-017-7108-8

Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole

ZHOU Jinhua, LI Jingjing, LI Jie, REN Guoyu, REN Yinghui, MA Haixia

School of Chemical Engineering, Northwest University, Xi'an 710069, P. R. China

收稿日期:2017-03-22 修回日期:2017-07-12 出版日期:2017-12-01 发布日期:2017-08-21
通讯作者: REN Yinghui,E-mail:mahx@nwu.edu.cn;MA Haixia,E-mail:yiren@nwu.edu.cn E-mail:mahx@nwu.edu.cn;yiren@nwu.edu.cn
基金资助:
Supported by the Provincial Key-point Natural Science Foundation of Shaanxi, China(No.2016JZ003) and the Training Program of Innovation and Entrepreneurship for Undergraduates in Northwest University, China(No.2016225).

Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole

ZHOU Jinhua, LI Jingjing, LI Jie, REN Guoyu, REN Yinghui, MA Haixia

School of Chemical Engineering, Northwest University, Xi'an 710069, P. R. China

Received:2017-03-22 Revised:2017-07-12 Online:2017-12-01 Published:2017-08-21
Contact: REN Yinghui,E-mail:mahx@nwu.edu.cn;MA Haixia,E-mail:yiren@nwu.edu.cn E-mail:mahx@nwu.edu.cn;yiren@nwu.edu.cn
Supported by:
Supported by the Provincial Key-point Natural Science Foundation of Shaanxi, China(No.2016JZ003) and the Training Program of Innovation and Entrepreneurship for Undergraduates in Northwest University, China(No.2016225).

摘要/Abstract

摘要： A new Co^Ⅱ complex,[CoL₄Cl₂]·2CH₃CH₂OH(L=hexaconazole), was synthesized and characterized by means of elemental analysis, infrared spectroscopy and single-crystal X-ray diffraction. The crystal structural analysis shows that the centrosymmetric Co²⁺ is coordinated by four hexaconazole ligands and two Cl^? to form a distorted octahedral geometry. The complex forms 1D chains through the intermolecular hydrogen bonds interaction of O-H…O and O-H…Cl. Furthermore, the antifungal activities of the complex against Grape anthracnose(I), Botryosphaeria berengriana(Ⅱ), Botryosphaeria ribis(Ⅲ) and Wheat gibberellic(IV) have been investigated and compared with those of the corresponding ligand. The results show that the complex has better antifungal activity than the ligand, which indicates that the coordination of the ligand and the metal enhances the antimicrobialactivity.

关键词: Co^IIcomplex, Hexaconazole, Crystal structure, Antifungal activity

Abstract: A new Co^Ⅱ complex,[CoL₄Cl₂]·2CH₃CH₂OH(L=hexaconazole), was synthesized and characterized by means of elemental analysis, infrared spectroscopy and single-crystal X-ray diffraction. The crystal structural analysis shows that the centrosymmetric Co²⁺ is coordinated by four hexaconazole ligands and two Cl^? to form a distorted octahedral geometry. The complex forms 1D chains through the intermolecular hydrogen bonds interaction of O-H…O and O-H…Cl. Furthermore, the antifungal activities of the complex against Grape anthracnose(I), Botryosphaeria berengriana(Ⅱ), Botryosphaeria ribis(Ⅲ) and Wheat gibberellic(IV) have been investigated and compared with those of the corresponding ligand. The results show that the complex has better antifungal activity than the ligand, which indicates that the coordination of the ligand and the metal enhances the antimicrobialactivity.

Key words: Co^IIcomplex, Hexaconazole, Crystal structure, Antifungal activity

ZHOU Jinhua, LI Jingjing, LI Jie, REN Guoyu, REN Yinghui, MA Haixia. Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole[J]. 高等学校化学研究, 2017, 33(6): 864-868.

ZHOU Jinhua, LI Jingjing, LI Jie, REN Guoyu, REN Yinghui, MA Haixia. Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole[J]. Chemical Research in Chinese Universities, 2017, 33(6): 864-868.

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Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole

Structure and Enhanced Antifungal Activity of a Divalent Cobalt(II) Complex with Hexaconazole

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