Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

Chemical Research in Chinese Universities ›› 2010, Vol. 26 ›› Issue (1): 66-69.

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Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

QIU Xue-peng^1,2*, KOSOBE Toshiyuki¹ and KAWASHIMA Norimichi^1*

1. Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama 225-8502, Japan;
2. Laboratory of Polymer Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2009-09-10 Revised:2009-10-09 Online:2010-01-04 Published:2010-03-29
Contact: QIU Xue-peng, E-mail: xp_q@ciac.jl.cn; KAWASHIMA Norimichi, E-mail: kawasima@cc.toin.ac.jp
Supported by:
Supported Partly by the Academic Frontier Promotion Grant from the Ministry of Education, Science, Sports and Culture, Japan and the Exchange Program Between the Japan Society of the Promotion of Science and the Chinese Academy of Sciences.

Abstract

Abstract:

A series of 5-aminolevulinic acid and its alkylester methanesulfonates was exploited to photodynamic therapy(PDT) of human lymphocytic cells, U-937 in vitro. The PDT efficiency is influenced by the concentration and incubation time. Generally, for ALA and its alkylester methanesulfonates, the cell survival rate decreases and the accumulation ability of PpIX increases with the concentration and incubation time. We found that the longer carbon chain methanesulfonates(C5-S, C6-S, C8-S) exhibit better PDT effect than ALA methanesulfonate. This possibly provides a promising route to the clinical application of PpIX-mediated PDT to cancer cell.

Key words: Photodynamic therapy; Methanesulfonate salt; 5-Aminolevulinic acid; Derivative; Cancer cell

QIU Xue-peng*, KOSOBE Toshiyuki and KAWASHIMA Norimichi1*. Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives[J]. Chemical Research in Chinese Universities, 2010, 26(1): 66-69.

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Photodynamic Therapy of Cancer Cells with Methanesulfonate Salts of 5-Aminolevulinic Acid and Its Derivatives

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