Chemical Research in Chinese Universities ›› 2010, Vol. 26 ›› Issue (1): 60-65.

• Articles • Previous Articles     Next Articles

Efficient Synthesis of 3,5,6,8-Tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones via an Iminophosphorane

LI Wen-jing, LIU Min, FENG Ling-ling* and DING Ming-wu*   

  1. Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. China
  • Received:2009-01-06 Revised:2009-02-23 Online:2010-01-04 Published:2010-03-29
  • Contact: DING Ming-wu. E-mail: ding5229@yahoo.com.cn; FENG Ling-ling. E-mail: fll708@mail.ccnu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20772041) and the Key Project of Chinese Ministry of Education(No.107082).

Abstract:

3,5,6,8-Tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones(7) were synthesized via the base catalytic reactions of amines or phenols with carbodiimides(5), which were obtained from the aza-Wittig reactions of iminophosphoranes(4) with aromatic isocyanates.

Key words: 3,5,6,8-Tetrahydro-4H-thiopyrano[4´,3´:4,5]thieno[2,3-d]pyrimidin-4-one; Aza-Wittig reaction; Carbodiimide; Isocyanate