Synthesis, Characterization and Application of Poly(lactic-co-glycolic acid) with a Mass Ratio of Lactic to Glycolic Segments of 52/48

doi:10.1007/s40242-022-2226-3

Chemical Research in Chinese Universities ›› 2023, Vol. 39 ›› Issue (2): 290-295.doi: 10.1007/s40242-022-2226-3

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Synthesis, Characterization and Application of Poly(lactic-co-glycolic acid) with a Mass Ratio of Lactic to Glycolic Segments of 52/48

QIN Chang¹, DONG Jing², XIE Beibei³, WANG Hongkun¹, ZHANG Na¹, ZHAO Chunhua¹, QIAO Congde², LIU Mingxia⁴, YANG Xiaodeng², LI Tianduo²

1. Engineering Technology Center, Shandong Guyuchun Biotechnology Co., Ltd., Jinan 250098, P. R. China;
2. Shandong Key Laboratory of Molecular Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, P. R. China;
3. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China;
4. Department of Blood Transfusion, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, P. R. China

Received:2022-07-03 Online:2023-04-01 Published:2023-03-16
Contact: YANG Xiaodeng, LI Tianduo, LIU Mingxia E-mail:yangxiaodeng@qlu.edu.cn;litianduo@163.com;liu.ming.xia7@163.com
Supported by:
This work was supported by the Major Research and Development Project of Shandong Province, China(No.2019JZZY011118), the Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province, China and the Project of the Jinan Science and Technology Bureau, China (No.2019GXRC021).

Abstract

Abstract: Poly(lactic-co-glycolic acid)(PLGA) is one of the most representative degradable copolymers and promising drug carriers. In the current paper, the PLGAs with a lactic acid/ glycolic acid(LA/GA) molar ratio of 52/48 and various molecular weights were prepared by a melting method. The molecular weight, molecular weight distribution, and thermal stability were determined by ¹H NMR and thermogravimetric analysis methods. The results demonstrated that PLGAs with the fixed LA/GA molar ratio(52/48), different molecular weights, and narrow molecular weight distribution could be obtained by solely altering the reaction time. The PLGA films were prepared, and their properties including micro-structure, mechanical property, in-vitro cytotoxicity, and biodegradability were characterized. In combination with the homogeneous microstructures and mechanical properties, the drug-loading and releasing properties of PLGA_3.2 films were investigated. The results show that PLGA_3.2 film with an LA/GA molar ratio of 52/48 is a promising curcumin carrier.

Key words: Poly(lactic-co-glycolic acid), Mechanical property, PLGA film, Drug carrier

QIN Chang, DONG Jing, XIE Beibei, WANG Hongkun, ZHANG Na, ZHAO Chunhua, QIAO Congde, LIU Mingxia, YANG Xiaodeng, LI Tianduo. Synthesis, Characterization and Application of Poly(lactic-co-glycolic acid) with a Mass Ratio of Lactic to Glycolic Segments of 52/48[J]. Chemical Research in Chinese Universities, 2023, 39(2): 290-295.

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Synthesis, Characterization and Application of Poly(lactic-co-glycolic acid) with a Mass Ratio of Lactic to Glycolic Segments of 52/48

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