CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (1): 68-72.

• Articles • Previous Articles     Next Articles

PRLs Promote Spreading, Adhesion, and Proliferation of Human SW480 and SW620 Cells

LI Zhao-fa1, XU Xue-song2, SHEN Xing-gui1, LI Qing-shan1, ZHAO Zhi-zhuang1, FU Xue-qi1, LI Yu-lin3, LI Yi-lei3   

  1. 1. Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun 130021, P. R. China;
    2. China-Japan Union Hospital, Jilin University, Changchun 13001, P. R. China;
    3. The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130023, P. R. China
  • Received:2005-03-02 Online:2006-02-24 Published:2011-08-06
  • Supported by:

    Supported by Open Foundation of State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University.

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Abstract: Recent studies suggest that PRL-3 is involved in the metastasis of colorectal cancer, but the mechanism concerning that has not been well defined. This article expresses PRL-1, PRL-2, and PRL-3 and the catalytically inactive mutant forms of those enzymes in SW620 and SW480 cells, two human cell lines derived from non-metastatic cancer and metastatic colorectal cancer, respectively. While the expression of the native forms of PRLs promotes the spreading, adhesion, and proliferation of these cells, the expression of their mutant forms inhibits the earlier-mentioned processes. These data thus provide a cellular mechanism for the role of PRL-3 in tumor metastasis and suggest that all the three PRLs have similar functions.

Key words: PRL, Metastasis, Proliferation, Expression, SW480 cell, SW620 cell