Design, Synthesis and Insecticidal Activities of Novel Phenyl Substituted Isoxazolecarboxamides

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (3): 430-433.

• Articles • Previous Articles Next Articles

Design, Synthesis and Insecticidal Activities of Novel Phenyl Substituted Isoxazolecarboxamides

LIU Peng-fei, ZHANG Ji-feng, YAN Tao, XIONG Li-xia, LI Zheng-ming

State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2011-08-29 Revised:2011-11-17 Online:2012-05-25 Published:2012-05-03
Contact: LI Zheng-ming E-mail:nkzml@vip.163.com
Supported by:
Supported by the National Natural Science Foundation of China(No. 20872069), the National Basic Research Program of China(No.2010CB126106) and the Fund of State Key Laboratory of Elemento-Organic Chemistry, China.

Abstract

Abstract: Thirteen novel phenyl substituted isoxazolecarboxamides were synthesized, and their structures were characterized by ¹H NMR, elementary analysis and high-resolution mass spectrometry(HRMS) techniques. Their evaluated insecticidal activities against oriental armyworm(Mythimna separata) indicate that the phenyl substituted isoxazolecarboxamides exhibited moderate insecticidal activities, among which compounds 9c and 9k showed comparatively higher activities.

Key words: Insecticidal activity, Isoxazole, Anthranilic diamide, Isoxazolecarboxamide

LIU Peng-fei, ZHANG Ji-feng, YAN Tao, XIONG Li-xia, LI Zheng-ming. Design, Synthesis and Insecticidal Activities of Novel Phenyl Substituted Isoxazolecarboxamides[J]. Chemical Research in Chinese Universities, 2012, 28(3): 430-433.

[1]	LI Huangong, ZHAO Yangyang, SUN Pengwei, GAO Li, XIONG Lixia, YANG Na, ZHOU Sha, LI Yuxin, LI Zhengming. Targeted Synthesis of Anthranilic Diamides Insecticides Containing Trifluoroethoxyl Phenylpyrazole [J]. Chemical Research in Chinese Universities, 2021, 37(3): 655-661.
[2]	FENG Fan, LI Jing, ZHANG Zhihui, FU Jiaxu, ZHANG Yumin, GU Qiang. Design, Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group [J]. Chemical Research in Chinese Universities, 2021, 37(3): 668-673.
[3]	ZHAO Yangyang, LI Huangong, SUN Pengwei, GAO Li, ZHOU Sha, XIONG Lixia, YANG Na, LI Yuxin, LI Zhengming. Design, Synthesis, Biological Evaluation and SARs of Anthranilic Diamide Derivatives Containing Pyrrole Moieties [J]. Chemical Research in Chinese Universities, 2020, 36(6): 1168-1173.
[4]	ZHANG Xiulan, ZHANG Huan, LIU Jingbo, XIONG Lixia, LI Zhengming. Synthesis and Biological Evaluation of Novel Anthranilic Diamides Containing N-H/CH₃-1H-Pyrazole [J]. Chemical Research in Chinese Universities, 2020, 36(5): 829-834.
[5]	ZHAO Yang, CHENG Jingli, XIE Zhengang, FANG Shaowei, ZHAO Jinhao. Syntheses and Insecticidal Activity of Spirocyclic Tetronic Acid Derivatives Containing Oxime Ether Moiety [J]. Chemical Research in Chinese Universities, 2020, 36(5): 810-815.
[6]	WANG Xianhao, LI Jianguo, WANG Guangjian, HAN Xianzheng, LI Dongmei, TIAN Zhongzhen. Design, Synthesis and Insecticidal Activities of Novel 5-Alkoxyfuran-2(5H)-one Derivatives [J]. Chemical Research in Chinese Universities, 2019, 35(5): 799-805.
[7]	HUA Xuewen, WEI Wei, ZHU Liangliang, ZHOU Yunyun. Synthesis and Bioactivity Evaluation of Novel N-Pyridylpyrazolemethanamine Derivatives [J]. Chemical Research in Chinese Universities, 2018, 34(5): 744-750.
[8]	LI Ling, ZOU Jiyong, XIA Qing, CUI Hongmin, YOU Shengyong, LIU Yuxiu, WANG Qingmin. Anti-TMV and Insecticidal Potential of Four Iridoid Glycosides from Gardenia Jasminoides Fruit [J]. Chemical Research in Chinese Universities, 2018, 34(5): 697-699.
[9]	LI Jing, LIU Hongwei, MENG Fanyu, YAN Liuqing, SHI Yanpeng, ZHANG Yumin, GU Qiang. Microwave-assisted Synthesis of New 1,2,3-Triazoles Bearing an Isoxazole Ring by the Azide-alkyne Cycloaddition Click Chemistry [J]. Chemical Research in Chinese Universities, 2018, 34(2): 197-202.
[10]	HUA Xuewen, LIU Chen, ZHOU Sha, CHEN Minggui, XIONG Lixia, LI Yongqiang, LI Zhengming. Design, Synthesis and Insecticidal Evaluation of Novel N-Pyridylpyrazolecarboxamide Derivatives Containing Isoxazole, Isoxazoline and 1,3,4-Thiadiazole Rings [J]. Chemical Research in Chinese Universities, 2017, 33(6): 882-889.
[11]	YANG Hongliang, XU Guoxing, PEI Yazhong. Synthesis, Preliminary Structure-activity Relationships and Biological Evaluation of Pyridinyl-4,5-2H-isoxazole Derivatives as Potent Antitumor Agents [J]. Chemical Research in Chinese Universities, 2017, 33(1): 61-69.
[12]	ZHANG Zhiqin, HE Xinwei, SHANG Yongjia, YU Zhiyu, WANG Sufan, WU Fuli. Ferrocenyl-isoxazole Derivative: a Novel Electrochemical, Colorimetric and Fluorescent Multiple Signal Probe for Highly Selective Recognition of Cu²⁺ Ions [J]. Chemical Research in Chinese Universities, 2017, 33(1): 31-35.
[13]	LIU Jingbo, LI Yuxin, CHEN Youwei, WU Changchun, WAN Yingying, WEI Wei, XIONG Lixia, ZHANG Xiao, YU Shujing, LI Zhengming. Design, Synthesis and Biological Activities of Novel Anthranilic Diamides Containing Dihydroisoxazoline and Isoxazole [J]. Chemical Research in Chinese Universities, 2016, 32(1): 41-48.
[14]	FANG Ting, SUN Chuanwen, XU Yiyi, YUAN Jing, WANG Yuanfeng, XING Jiahua. Synthesis, Insecticidal Activities and Molecular Docking Studies on cis-Nitenpyram Analogues with a Flexible Amido Segment Anchored on Tetrahydropyrimidine Ring [J]. Chemical Research in Chinese Universities, 2014, 30(6): 931-936.
[15]	LI Yuedong, MAO Wutao, FAN Zhijin, LI Juanjuan, FANG Zhen, JI Xiaotian, ZONG Guangning, LI Fengyun. Synthesis and Biological Activities of Novel 1,2,4-Triazole Derivatives Containing 1,2,3-Thiadiazole Ring [J]. Chemical Research in Chinese Universities, 2014, 30(3): 390-395.

Design, Synthesis and Insecticidal Activities of Novel Phenyl Substituted Isoxazolecarboxamides

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments