Association of UCP3, APN, and TNF-α Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients

Chemical Research in Chinese Universities ›› 2012, Vol. 28 ›› Issue (2): 255-258 .

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Association of UCP3, APN, and TNF-α Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients

WANG Ling-ling^1,3, DU Zhen-wu¹, LIU Jia-nan¹, WU Mei¹, SONG Yang², JIANG Ri-hua¹, ZHANG Gui-zhen¹

1. Central Research Department, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;
2. Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China;
3. Department of Neurology, the Affiliated Hospital of Beihua University, Jilin 132000, P. R. China

Received:2011-10-17 Revised:2011-12-06 Online:2012-03-25 Published:2012-03-08
Supported by:
Supported by the Scientific Research Foundation of Jilin Province, China(Nos.2007-0722, 2008-2123, 20100942) and the Grants from the Developing and Reforming Community of Jilin Provinces, China(Nos.2006-1550, 20080925, 2010-1928).

Abstract

Abstract: We observed the polymorphism distribution and coaction of uncoupling protein 3(UCP3)-55C/T, adipo-nectin(APN)+45T/G and tumor necrosis factor(TNF)-α-308G/A on the onset and development of T2DM in a Northern Chinese Han population of 213[100 type 2 diabete(T2DM) patients and 113 health control subjects] by polymerase chain reaction-restriction fragment length polymorphisum(PCR-RFLP) method. Results demonstrate the polymorphism of UCP3-55C/T, APN+45T/G, and TNF-α-308G/A related to T2DM onset and developement. And the individuals carrying UCP3-55T, APN+45G and TNF-α-308A allele had higher T2DM risk. Those results are the first report to evaluate the association of the coaction of UCP3, APN, TNF-α genes polymorphism on T2DM risk and the susceptibility of T2DM in the Northern Chinese Han population.

Key words: Uncoupling protein 3(UCP3), Adiponectin(APN), Tumor necrosis factor(TNF)-α, Gene polymorphism, Type 2 diabete(T2DM) risk

WANG Ling-ling, DU Zhen-wu, LIU Jia-nan, WU Mei, SONG Yang, JIANG Ri-hua, ZHANG Gui-zhen. Association of UCP3, APN, and TNF-α Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients[J]. Chemical Research in Chinese Universities, 2012, 28(2): 255-258 .

References

[1] Lee H. J., Ryu H. J., Shin H. D., Park B. L., Kim J. Y., Cho Y. M., Park K. S., Song J., Oh B., Clin. Chim. Acta., 2008, 398(1/2), 27 [2] Li Y., Li X., Shi L., Yang M., Yang Y., PLoS One, 2011, 6(5), e19686 [3] Guzmán-Flores J. M., Muñoz-Valle J. F., Sánchez-Corona J., Cobián J. G., Medina-Carrillo L., Dis. Markers, 2011, 30(1), 19 [4] Zaninovich A. A., Medicina(B Aires), 2005, 65(2), 163 [5] Chan C. B., Harper M. E., Curr. Diabetes Rev., 2006, 2(3), 271 [6] Jezek P., Int. J. Biochem. Cell. Biol., 2002, 34(10), 1190 [7] Menzaghi C., Ercolino T., Di Paola R., Berg A. H., Warram J. H., Scherer P. E., Diabetes, 2002, 51(7), 2306 [8] Schöffler A., Barth N., Palitzsch K. D., Drobnik W., Schölmerich J., Schmitz G., Eur. J. Clin. Invest., 2000, 30(10), 879 [9] Hara K., Boutin P., Mori Y., Tobe K., Dina C., Yasuda K., Yamauchi T., Otabe S., Diabetes, 2002, 51(2), 536 [10] Nakatani K., Noma K., Nishioka J., Int. J. Mol. Med., 2005, 15(1), 173 [11] Zacharova J., Chiasson J. L., Laakso M., Diabetes, 2005, 54(3), 893 [12] Li L. L., Kang X. L., Ran X. J., Wang Y., Wang C. H., Huang L., Ren J., Luo X., Mao X. M., Clin. Exp. Pharmacol Physiol, 2007, 34(12), 1287 [13] Wang Y., Zhang J., Huang Q. Y., Hereditary, 2008, 30(6), 711 [14] Xu M. T., Chen X. C., Jin L. Z., Chen W. Q., Chinese Journal of Epidemiology, 2008, 29(11), 1132 [15] Lee J. M., Kim S. R., Yoo S. J., Hong O. K., Son H. S., Chang S. A., J. Int. Med. Res., 2009, 37(6), 1803 [16] Chang Y., Niu X. M., Qi X. M., Zhang H. Y., Li N. J., Luo Y., Chinese Journal of Obstetrics and Gynecology, 2005, 40(10), 676 [17] Fernandez-Real J. M., Vendrell J., Ricart V. V., Diabetes Care, 2000, 23(6), 831 [18] Wilson A. G., Symons J. A., McDowell T. L., McDevitt H. O., Duff G. W., Proc. Natl. Acad. Sci. USA, 1997, 94(7), 3195 [19] Fang Q., Xiang K., Lu J., Chimese Medical Journal, 1999, 79(5), 343 [20] Lzawa H., Yamada Y. J., Okada T., J. Cardiol, 2004, 43(2), 92 [21] Day C. P., Grove J., Daly A. K., Stewart M. W., Avery P. J., Walker M., Diabetologia, 1998, 41(4), 430 [22] Pulkkinen L., Ukkola O., Kolehmainen M., Uusitupa M., Int. J. Pept., 2010, 1 [23] Jin W., Patti M. E., Clin. Sci.(London), 2009, 116(2), 99 [24] Wu M., Du Z. W., Liu J. N., Song Y., Wang Y. L., Zhang G. Z., Chem. Res. Chinese Universities, 2010, 26(2), 259 [25] Zhang G. Z., Li M. H., Song Y., Liu T., Gao S., Sun Y., Chem. Res. Chinese Universities, 2007, 23(6), 701

Association of UCP3, APN, and TNF-α Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients

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