CRCU

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (6): 981-983.

• Articles • Previous Articles     Next Articles

New Way to Synthesize DW286―a Novel Fluoronaphthyridone Antibacterial Agent

FENG Lian-shun, LIU Ming-liang*, ZHANG Yi-bin and GUO Hui-yuan   

  1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China
  • Received:2010-12-06 Revised:2011-04-27 Online:2011-11-25 Published:2011-11-07
  • Contact: LIU Ming-liang E-mail:lmllyx@yahoo.com.cn
  • Supported by:

    Supported by the National S&T Major Special Project of China on Major New Drug Innovation(No.2009ZX09301-003).

PDF (PC)

Abstract: A new route for the synthesis of DW286, 7-[3-(aminomethyl)-4-(methoxyimino)-3-methyltetrahy- dro-1H-1-pyrrolyl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid hydrochloric acid salt, is described. In the presence of benzadehyde, DW286 was prepared by the direct condensation of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid with new pyrrolidine derivative 7 which could be obtained by routine reactions.

Key words: DW286, Benzadehyde, Direct condensation