CRCU

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (6): 977-980.

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Synthesis of 2-Phenyl-10-substituted Hymenialdisine Derivatives

WU Yi, WANG Yu, QIN Yong and SONG Hao*   

  1. Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China
  • Received:2010-12-09 Revised:2011-09-02 Online:2011-11-25 Published:2011-11-07
  • Contact: SONG Hao E-mail:songhao@scu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.21002066) and the Scientific Research Foundation for Young Teachers of Sichuan University, China(No.2009SCU11181).

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Abstract: A series of novel 2-phenyl-10-substituted hymenialdisine derivatives was synthesized via the microwave-assisted Suzuki-Miyaura cross-coupling reactions of the 2-phenyl derivative of hymenialdisine and boronic acid, which enabled the successful introduction of electron-donating and electron-withdrawing groups to the 2-phenyl- hymenialdisine derivatives in good yields.

Key words: Hymenialdisine, Suzuki-Miyaura reaction, 2-Phenyl-10-substituted hymenialdisine derivative