CRCU

Chemical Research in Chinese Universities ›› 2011, Vol. 27 ›› Issue (2): 170-173.

• Articles • Previous Articles     Next Articles

Novel Chiral PNNP-Ru Complexes: Synthesis and Application in Asymmetric Transfer Hydrogenation of Ketones

CHENG Zhi-bo1, YU Shen-luan1, LI Yan-yun1, DONG Zhen-rong1, SUN Guo-song2, HUANG Ke-lin2 and GAO Jing-xing1*   

  1. 1. State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China;
    2. Guangxi Research Institute of Chemical Industry, Nanning 530001, P. R. China
  • Received:2010-03-15 Revised:2010-07-07 Online:2011-03-25 Published:2011-03-09
  • Contact: GAO Jing-xing E-mail:cuihua@xmu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.20423002, 20703034), the Natural Science Foundation of Fujian Province of China(No.2008J0235) and the Natural Science Foundation of Guangxi Province of China(No. 0991016).

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Abstract: The efficient catalytic systems generated in situ from RuCl2(PPh3)3 and chiral ligands N,N-bis[2-(di-o- tolylphosphino)-benzyl]cyclohexane-1,2-diamine(2) were employed for asymmetric transfer hydrogenation of aromatic ketones, giving the corresponding optically active alcohols with high activities(up to 99% conversion) and excellent enantioselectivities(up to 96% e.e.) under mild conditions. The chiral ruthenium(II) complex (R,R)-3 has been prepared and characterized by NMR and X-ray crystallography.

Key words: Chiral PNNP ligand, Ru complex, Asymmetric transfer hydrogenation, Aromatic ketone