Determination and Correlation of 1-Octanol/Water Partition Coefficients for Six Quinolones from 293.15 K to 323.15 K

Chemical Research in Chinese Universities ›› 2010, Vol. 26 ›› Issue (4): 636-639.

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Determination and Correlation of 1-Octanol/Water Partition Coefficients for Six Quinolones from 293.15 K to 323.15 K

ZHANG Cong-liang* and WANG Yan

College of Chemical Engineering, Zhengzhou University, Zhengzhou 450002, P. R. China

Received:2009-10-15 Revised:2010-01-12 Online:2010-07-25 Published:2010-10-01
Contact: ZHANG Cong-liang, E-mail: zhangcl201@zzu.edu.cn
Supported by:
Supported by the Natural Science Foundation of Henan Province, China(No.0611033400).

Abstract

Abstract: A shake-flask method was used to determine 1-octanol/water partition coefficients of ofloxacin, norflo- xacin, lomefloxacin, ciprofloxacin, pefloxacin and pipemidic acid from 293.15 K to 323.15 K. The results show that 1-octanol/water partition coefficient of each quinolone increased with the increase of temperature. Based on the fluid phase equilibrium theory, the thermodynamic relationship of 1-octanol/water partition coefficient depending on the temperature was proposed, and the changes of enthalpy, entropy, and Gibbs free energy for quinolones partitioning in 1-octanol/water were determined, respectively. Quinolones molecules partitioning in 1-octanol/water was mainly an entropy driving process, during which the order degree of system decreased. The temperature effects of 1-octanol/water partition coefficient were investigated. The results show that its magnitude is the same as the values in the literature.

Key words: Quinolone, 1-Octanol/water partition coefficient, Thermodynamics

ZHANG Cong-liang* and WANG Yan. Determination and Correlation of 1-Octanol/Water Partition Coefficients for Six Quinolones from 293.15 K to 323.15 K[J]. Chemical Research in Chinese Universities, 2010, 26(4): 636-639.

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Determination and Correlation of 1-Octanol/Water Partition Coefficients for Six Quinolones from 293.15 K to 323.15 K

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