Biopolymer Entering into and Escaping from a Nanometer Pore

Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (6): 945-949.

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Biopolymer Entering into and Escaping from a Nanometer Pore

DING Ke-jian¹, ZHENG Yan-peng¹, GUAN Wei-jun^2* and MA Yue-hui^2*

1. College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing 100044, P. R. China;
2. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China

Received:2008-10-17 Revised:2009-03-10 Online:2009-11-25 Published:2010-01-25
Contact: MA Yue-hui, E-mail: yuehui.ma@263.net; GUAN Wei-jun, E-mail: wjguan86@iascaas.net.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.10704007), National Infrastructure of Natural Science and Technology Program(No.2005DKA21101) and the Chinese National Science and Technology Pillar Program for the Eleventh Five-year Plan(No.2006BAD13B08).

Abstract

Abstract:

We theoretically investigated negative entropy S of biopolymer which passes through a nanometer pore(such as α-hemolysin), especially entering process and escaping process, on the basis of which we also studied biopolymer entering-pore time τ_ent, biopolymer entering mean velocity v_ent, biopolymer escaping-pore time τ_esc, and biopolymer escaping mean velocity v_esc, respectively. Our results illustrate that the entering and escaping processes of biopolymer depend on its negative entropy, and entering process is more difficult than escaping process for biopolymer translocation. This tremendous difference between the two processes will offer a useful engineering hint for single macromolecule identification.

Key words: Biopolymer; Nanometer pore; Negative entropy; Entering; Escaping

DING Ke-jian, ZHENG Yan-peng, GUAN Wei-jun* and MA Yue-hui*. Biopolymer Entering into and Escaping from a Nanometer Pore[J]. Chemical Research in Chinese Universities, 2009, 25(6): 945-949.

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Biopolymer Entering into and Escaping from a Nanometer Pore

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